ArticleThe American journal of psychiatry2018
Altered Brain Developmental Trajectories in Adolescents After Initiating Drinking.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 183 citations in OpenAlex.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- Associations between video gaming behaviors and cortical morphology in adolescents.NeuroImage · 2026Article
- Divergent Pathways Taken in Adolescence Predict Embracing or Resisting Moderate-to-Heavy Drinking in Young Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Prenatal antioxidant treatment suppresses maternal immune activation induced increases in alcohol self-administration in a sex-specific manner.Psychopharmacology · 2026Article
- The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review.Biomedicines · 2025Review
- Assessing orbitofrontal cortex volume as a predictor of subjective response to alcohol during early adolescence.Alcohol (Fayetteville, N.Y.) · 2025Article
- Adolescent suicide behaviors associate with accelerated reductions in cortical gray matter volume and slower decay of behavioral activation Fun-Seeking scores.Scientific reports · 2025Article
- Socioemotional and Executive Control Mismatch in Adolescence and Risks for Initiating Drinking.JAMA network open · 2025Article
- Personalized Feedback in Parent-Based Interventions to Prevent or Reduce Adolescent Drinking.Journal of studies on alcohol and drugs · 2025Article
- Physiological and brain mechanisms contributing to postural tremor in aging with and without alcohol use disorder.Translational psychiatry · 2025Article
- Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study.Translational psychiatry · 2025Article
- Clinical Characteristics and Treatment Outcomes of Alcohol Withdrawal Syndrome in Adolescents and Young Adults.JAACAP open · 2025Article
- Spectral Graph Sample Weighting for Interpretable Sub-cohort Analysis in Predictive Models for Neuroimaging.Predictive Intelligence in Medicine. PRIME (Workshop) · 2025Article
- Measuring Character Strengths and Promoting Positive Youth Development in Zambia: Initial Findings from the GROW Hopes for Life Study.Child & youth care forum · 2025Article
- Neurobiological intersections of stress and substance use disorders.Frontiers in neuroscience · 2025Review
- An investigation of multimodal predictors of adolescent alcohol initiation.Drug and alcohol dependence · 2024Article
- Association between adolescent alcohol use and cognitive function in young adulthood: A co-twin comparison study.Addiction (Abingdon, England) · 2024Article
- A longitudinal study of the relationship between alcohol-related blackouts and attenuated structural brain development.Developmental cognitive neuroscience · 2024Article
- Hippocampal gray matter volume in young adulthood varies with adolescent alcohol use.Experimental and clinical psychopharmacology · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Adolf PfefferbaumFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Dongjin KwonFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Ty BrumbackFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Wesley K ThompsonFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Kevin CumminsFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Susan F TapertFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Sandra A BrownFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Ian M ColrainFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Fiona C BakerFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Devin ProutyFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Michael D De BellisFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Duncan B ClarkFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Bonnie J NagelFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Weiwei ChuFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Sang Hyun ParkFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Kilian M PohlFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Edith V SullivanFrom the Center for Health Sciences, SRI International, Menlo Park, Calif.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; the Department of Psychiatry, University of California, San Diego, La Jolla; the Department of Family Medicine and Public Health, University of California, San Diego; the Healthy Childhood Brain Development Research Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry, University of Pittsburgh, Pittsburgh; the Department of Psychiatry and the Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland; and the Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea.
Stanford University · US
Funding
Sex Differences in Autonomic Nervous System Function and Depression Across AdolescenceU01AA021696 · NIAAA · SRI INTERNATIONAL · PI Fiona C Baker · 2012 to 2026
$12.2MNCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2MNational Consortium on Alcohol and NeuroDevelopment in Adolescence: San DiegoU01AA021692 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Susan F. Tapert · 2012 to 2026
$11.8MNCANDA Research Project Site: DukeU01AA021681 · NIAAA · DUKE UNIVERSITY · PI DAVID B. GOLDSTON · 2012 to 2026
$9.8MThe TEEN Study: The Impact of Adolescent Drinking on Connectivity in the BrainU01AA021691 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angelica Marie Morales, Bonnie J. Nagel · 2012 to 2026
$8.5MNCANDA Research Project Site: University of Pittsburgh (NCANDA-PITT)U01AA021690 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN B. CLARK, BEATRIZ LUNA · 2012 to 2026
$7.6MNational Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative ResourceU24AA021695 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, Susan F. Tapert · 2016 to 2026
$6.0MN-CANDA: DATA ANALYSIS COMPONENTU01AA021697 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, POHL, KILIAN MARIA · 2012 to 2015
$3.6MTranslational Studies of Brain Circuitry Disrupted by AlcoholismK05AA017168 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2008 to 2017
$2.2MNational Consortium on Alcohol and NeuroDevelopment in Adolescence: AdminU01AA021695 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, SANDRA A, TAPERT, SUSAN F · 2012 to 2015
$2.1MNIAAA NIH HHS K05 AA017168NIAAA NIH HHS U01 AA021681NIAAA NIH HHS U01 AA021690NIAAA NIH HHS U01 AA021691NIAAA NIH HHS U01 AA021692NIAAA NIH HHS U01 AA021695NIAAA NIH HHS U01 AA021696NIAAA NIH HHS U01 AA021697NIAAA NIH HHS U24 AA021695NIAAA NIH HHS U24 AA021697
Abstract
objectiveThe authors sought evidence for altered adolescent brain growth trajectory associated with moderate and heavy alcohol use in a large national, multisite, prospective study of adolescents before and after initiation of appreciable alcohol use.
methodThis study examined 483 adolescents (ages 12-21) before initiation of drinking and 1 and 2 years later. At the 2-year assessment, 356 participants continued to meet the study's no/low alcohol consumption entry criteria, 65 had initiated moderate drinking, and 62 had initiated heavy drinking. MRI was used to quantify regional cortical and white matter volumes. Percent change per year (slopes) in adolescents who continued to meet no/low criteria served as developmental control trajectories against which to compare those who initiated moderate or heavy drinking.
resultsIn no/low drinkers, gray matter volume declined throughout adolescence and slowed in many regions in later adolescence. Complementing gray matter declines, white matter regions grew at faster rates at younger ages and slowed toward young adulthood. Youths who initiated heavy drinking exhibited an accelerated frontal cortical gray matter trajectory, divergent from the norm. Although significant effects on trajectories were not observed in moderate drinkers, their intermediate position between no/low and heavy drinkers suggests a dose effect. Neither marijuana co-use nor baseline volumes contributed significantly to the alcohol effect.
conclusionsInitiation of drinking during adolescence, with or without marijuana co-use, disordered normal brain growth trajectories. Factors possibly contributing to abnormal cortical volume trajectories include peak consumption in the past year and family history of alcoholism.
Indexed as
AdolescentAge FactorsAlcohol DrinkingBrainCannabisCase-Control StudiesCerebral CortexChildDose-Response Relationship, DrugFemaleFollow-Up StudiesFrontal LobeGray MatterHumansMagnetic Resonance ImagingMaleAdolescentsAlcohol AbuseBrain Imaging Techniques
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