ArticleJAMA internal medicine2018
Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.
Article in JAMA internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.Frontiers in public health · 2025Pooled it
- A Systematic Review of Organic Versus Conventional Food Consumption: Is There a Measurable Benefit on Human Health?Nutrients · 2019Pooled it
- Male partner pesticide residue exposure from fruit and vegetable intake in relation to outcomes of infertility treatment: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Pregnancy urinary phenol biomarker concentrations in relation to serum levels of inflammatory cytokines: Results from the EARTH study.Environment international · 2025Article
- Human sperm as an in vitro toxicity model: a versatile tool for assessing the risk of environmental contaminants.Archives of toxicology · 2025Article
- Effect Modification of Serum Omega-3 Fatty Acids on the Associations between Urinary Phthalate Biomarkers Mixture and Pregnancy Outcomes among Women Seeking Fertility Care.Environmental health perspectives · 2025Article
- Associations of Pesticide Residue Exposure from Fruit and Vegetable Intake with Ovarian Reserve.The Journal of nutrition · 2025Article
- Metabolic Mechanisms Underlying the Association Between the Profertility Diet and In Vitro Fertilization End Points.The Journal of nutrition · 2025Article
- From field to plate: 50 years of plant-based food production and emerging risks to planetary and women's health.Frontiers in nutrition · 2025Article
- A study protocol for a randomized clinical trial on exposure and effects of pesticides consumption - the PEST-EXPO Brazil study.MethodsX · 2024Article
- Exposure to Environmental Chemicals and Infertility Among US Reproductive-Aged Women.International journal of environmental research and public health · 2024Article
- Dietary Patterns and Fertility.Biology · 2024Review
- A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health.Foods (Basel, Switzerland) · 2024Review
- Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies.Human reproduction update · 2023Article
- The effect of serum calcium on the association of depression with infertility among U.S. women.Heliyon · 2023Article
- Associations between Urinary Concentrations of Disinfection Byproducts andEnvironmental health perspectives · 2023Article
- The role of endocrine disruptors in female infertility.Molecular biology reports · 2023Review
- Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.Current developments in nutrition · 2023Article
- Acute exposure to organophosphorus pesticide metabolites compromises buffalo sperm function and impairs fertility.Scientific reports · 2023Article
- Fruit and vegetable consumption, pesticide residue intake from consumption of fruits and vegetables, and risk of uterine fibroids.F&S science · 2023Article
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11 authors.
Funding
Abstract
Importance: Animal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown. Objective: To examine the association of preconception intake of pesticide residues in fruits and vegetables (FVs) with outcomes of infertility treatment with assisted reproductive technologies (ART). Design, Setting, and Participants: This analysis included 325 women who completed a diet assessment and subsequently underwent 541 ART cycles in the Environment and Reproductive Health (EARTH) prospective cohort study (2007-2016) at a fertility center at a teaching hospital. We categorized FVs as having high or low pesticide residues using a validated method based on surveillance data from the US Department of Agriculture. Cluster-weighted generalized estimating equations were used to analyze associations of high- and low-pesticide residue FV intake with ART outcomes. Main Outcomes and Measures: Adjusted probabilities of clinical pregnancy and live birth per treatment cycle. Results: In the 325 participants (mean [SD] age, 35.1 [4.0] y; body mass index, 24.1 [4.3]), mean (SD) intakes of high- and low-pesticide residue FVs were 1.7 (1.0) and 2.8 (1.6) servings/d, respectively. Greater intake of high-pesticide residue FVs was associated with a lower probability of clinical pregnancy and live birth. Compared with women in the lowest quartile of high-pesticide FV intake (<1.0 servings/d), women in the highest quartile (≥2.3 servings/d) had 18% (95% CI, 5%-30%) lower probability of clinical pregnancy and 26% (95% CI, 13%-37%) lower probability of live birth. Intake of low-pesticide residue FVs was not significantly related to ART outcomes. Conclusions and Relevance: Higher consumption of high-pesticide residue FVs was associated with lower probabilities of pregnancy and live birth following infertility treatment with ART. These data suggest that dietary pesticide exposure within the range of typical human exposure may be associated with adverse reproductive consequences.
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