ArticlePLoS neglected tropical diseases2017
Molecular characterization and phylogenetic relatedness of dog-derived Rabies Viruses circulating in Cameroon between 2010 and 2016.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Holistic application of the one health approach in the prevention and control of rabies: plausible steps towards achieving the 2030 vision in Africa.One health outlook · 2024Review
- Geographic Distribution of Rabies Virus and Genomic Sequence Alignment of Wild and Vaccine Strains, Kenya.Emerging infectious diseases · 2024Article
- Comparing the genetic typing methods for effective surveillance and rabies control in Georgia.Frontiers in microbiology · 2023Article
- Making genomic surveillance deliver: A lineage classification and nomenclature system to inform rabies elimination.PLoS pathogens · 2022Article
- Molecular analyses of human rabies virus associated with encephalitis in two children in Gabon.IJID regions · 2022Article
- Rabies in the Tropics.Current tropical medicine reports · 2022Review
- Rabies is still a fatal but neglected disease: a case report.Journal of medical case reports · 2021Article
- Incidence and seroprevalence of rabies virus in humans, dogs and other animal species in Africa, a systematic review and meta-analysis.One health (Amsterdam, Netherlands) · 2021Review
- On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study.Viruses · 2021Review
- Molecular characterization of rabies viruses from two western provinces of the Democratic Republic of the Congo (2008-2017).Virus genes · 2020Article
- Rabies in Uganda: rabies knowledge, attitude and practice and molecular characterization of circulating virus strains.BMC infectious diseases · 2020Article
- Molecular detection of rabies virus strain with N-gene that clustered with China lineage 2 co-circulating with Africa lineages in Monrovia, Liberia: first reported case in Africa.Epidemiology and infection · 2019Article
- The influence of poverty and rabies knowledge on healthcare seeking behaviors and dog ownership, Cameroon.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabies is enzootic among dog populations in some parts of Cameroon and the risk of human rabies is thought to be steadily high in these regions. However, the molecular epidemiology of circulating Rabies Virus (RABV) has been hardly considered in Cameroon as well as in most neighboring central African countries. To address this fundamental gap, 76 nucleoprotein (N) gene sequences of dog-derived RABV were obtained from 100 brain specimens sampled in Cameroon from 2010 to 2016. Studied sequences were subjected to molecular and phylogenetic analyses with reference strains retrieved from databases. The 71 studied Africa-1 isolates displayed 93.5-100% nucleotide (nt) and 98.3-100% amino-acid (aa) identities to each other while, the 5 studied Africa-2 isolates shared 99.4-99.7% sequence similarities at nt and aa levels. Maximum Likelihood based phylogenies inferred from nucleotide sequences confirmed all studied RABV isolates as members of the dog-related species 1 of the Lyssavirus genus. Individual isolates could be unambiguously assigned as either the Africa-1 subclade of the Cosmopolitan clade or the Africa 2 clade. The Africa-1 subclade appeared to be more prevalent and diversified. Indeed, 70 studied isolates segregated into 3 distinct circulating variants within Africa-1a lineage while a unique isolate was strikingly related to the Africa-1b lineage known to be prevalent in the neighboring Central African Republic and eastern Africa. Interestingly, all five Africa-2 isolates fell into the group-E lineage even though they appeared to be loosely related to databases available reference RABV; including those previously documented in Cameroon. This study uncovered the co-circulation of several Africa-1 and Africa-2 lineages in the southern regions of Cameroon. Striking phylogenetic outcasts to the geographic differentiation of RABV variants indicated that importation from close regions or neighboring countries apparently contributes to the sustainment of the enzootic cycle of domestic rabies in Cameroon.
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