ArticlePLoS genetics2017
A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- A memory transcriptome time course reveals essential long-term memory transcription factors.Nature communications · 2025Article
- Memory phase-specific genes in the Mushroom Bodies identified using CrebB-target DamID.PLoS genetics · 2023Article
- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning.Journal of visualized experiments : JoVE · 2021Article
- Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster.Cell stress & chaperones · 2021Article
- The Making of Long-Lasting Memories: A Fruit Fly Perspective.Frontiers in behavioral neuroscience · 2021Review
- Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence.EMBO reports · 2020Article
- Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.Communications biology · 2020Article
- Article
- Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression.eLife · 2019Article
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach.eLife · 2019Article
- NewG3 (Bethesda, Md.) · 2019Article
- Mushroom Body Specific Transcriptome Analysis Reveals Dynamic Regulation of Learning and Memory Genes After Acquisition of Long-Term Courtship Memory inG3 (Bethesda, Md.) · 2018Article
- Antimicrobial peptides modulate long-term memory.PLoS genetics · 2018Article
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Authors and funding
6 authors.
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Abstract
The ability to integrate experiential information and recall it in the form of memory is observed in a wide range of taxa, and is a hallmark of highly derived nervous systems. Storage of past experiences is critical for adaptive behaviors that anticipate both adverse and positive environmental factors. The process of memory formation and consolidation involve many synchronized biological events including gene transcription, protein modification, and intracellular trafficking: However, many of these molecular mechanisms remain illusive. With Drosophila as a model system we use a nonassociative memory paradigm and a systems level approach to uncover novel transcriptional patterns. RNA sequencing of Drosophila heads during and after memory formation identified a number of novel memory genes. Tracking the dynamic expression of these genes over time revealed complex gene networks involved in long term memory. In particular, this study focuses on two functional gene clusters of signal peptides and proteases. Bioinformatics network analysis and prediction in combination with high-throughput RNA sequencing identified previously unknown memory genes, which when genetically knocked down resulted in behaviorally validated memory defects.
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