ArticleEuropean journal of gastroenterology & hepatology2017
Lymph node metastasis can be determined by just tumor depth and lymphovascular invasion in early gastric cancer patients after endoscopic submucosal dissection.
Article in European journal of gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and risk factors for lymph node metastasis after noncurative endoscopic resection for early gastric cancer: a systematic review and meta-analysis.Journal of gastroenterology · 2020Pooled it
- Article
- Management Strategy of Non-curative ESD in Gastric Cancer: Curative Criteria, and the Critical Building Block for Determining Beyond It.Journal of gastric cancer · 2025Review
- A computed tomography‑based radio‑clinical model for the prediction of microvascular invasion in gastric cancer.Molecular and clinical oncology · 2024Article
- Value of quantitative microsurface structure analysis for evaluating the invasion depth of type 0-II early gastric cancer.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- A novel prediction model of pancreatic fistula after pancreaticoduodenectomy using only preoperative markers.BMC surgery · 2023Article
- Tumor size as a significant prognostic factor in T1 gastric cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis.BMC gastroenterology · 2023Article
- Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders.Heliyon · 2023Article
- CD4 and FOXP3 as predictive markers for the recurrence of T3/T4a stage II colorectal cancer: applying a novel discrete Bayes decision rule.BMC cancer · 2022Article
- Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold.World journal of gastroenterology · 2021Review
- Patterns of Lymph Node Metastasis in Patients With T1/T2 Gastroduodenal Neuroendocrine Neoplasms: Implications for Endoscopic Treatment.Frontiers in endocrinology · 2021Article
- Article
- Prognostic factors for ESD of early gastric cancers: a systematic review and meta-analysis.Endoscopy international open · 2020Review
- Intramucosal-lymphatic invasion has a slight impact on lymph node metastasis in patients with early gastric cancer.Surgery today · 2020Article
- Blood Free-Circulating DNA Testing of Methylated RUNX3 Is Useful for Diagnosing Early Gastric Cancer.Cancers · 2020Article
- Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Predictive factors for lymph node metastasis and defining a subgroup treatable for laparoscopic lymph node dissection after endoscopic submucosal dissection in poorly differentiated early gastric cancer.World journal of gastrointestinal oncology · 2018Article
- Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.Oncology letters · 2018Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEndoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric cancer (EGC) with negligible risk of lymph node metastasis (LNM). When a patient is determined to have noncurative resection after ESD, additional surgical resection with lymph node dissection is recommended. Previous studies report that LNM is found in about 10% of these patients. It may be possible to avoid unnecessary surgical resection by selecting patients properly. We aimed to clarify the risk factors associated with LNM in EGC patients who underwent ESD and to develop a highly accurate diagnostic algorithm for LNM. PATIENTS AND
methodsAmong 1005 patients with EGC who underwent ESD, 423 patients who could be followed up for more than 3 years after treatment or who underwent additional surgical resection were examined. We used the leave-one-out method to explore the combination of predictive factors of LNM and differentiated LNM by a unique classifier.
resultsCurative resection was achieved in 322 patients, whereas noncurative resection was achieved in 101 patients. In the noncurative resection group, LNM occurred in eight patients with additional surgical resection and one patient during follow-up. The combination of depth of invasion, lymphatic, and venous invasion showed the highest diagnostic performance and could differentiate LNM with 100% sensitivity, 86% specificity, and 86% diagnostic accuracy.
conclusionMore than 500 μm submucosal invasion and lymphatic and venous invasion will be useful in assessing LNM after ESD for patients with EGC. When these three factors are not observed, follow-up alone might be appropriate and it may be possible to reduce unnecessary surgical resection.
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