Evidence map›Paper›PMID 29084046›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

Using Clinical Notes and Natural Language Processing for Automated HIV Risk Assessment.

Daniel J Feller, Jason Zucker, Michael T Yin, Peter Gordon, Noémie Elhadad

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Identify Patients at Risk of HIV Using a Clinical Large Language Model from Electronic Health Records.Proceedings. IEEE International Conference on Healthcare Informatics · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel J FellerDepartment of Biomedical Informatics, Columbia University, New York, NY.
Jason ZuckerDivision of Infectious Diseases, Department of Medicine, Columbia University, New York, NY.
Michael T YinDivision of Infectious Diseases, Department of Medicine, Columbia University, New York, NY.
Peter GordonDivision of Infectious Diseases, Department of Medicine, Columbia University, New York, NY.
Noémie ElhadadDepartment of Biomedical Informatics, Columbia University, New York, NY.

Funding

Training in Biomedical Informatics at Columbia UniversityT15LM007079 · NLM · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NOEMIE ELHADAD, GEORGE M HRIPCSAK · 1992 to 2026
$28.9M
Extended Methods and Software Development for Health NLPR01GM114355 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BETHARD, STEVEN, SAVOVA, GUERGANA K. · 2016 to 2024
$5.0M
Training in Pediatric Infectious DiseasesT32AI007531 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PRINCE, ALICE S, SAIMAN, LISA · 1998 to 2023
$4.0M
NIAID NIH HHS L30 AI133789NIAID NIH HHS T32 AI007531NIGMS NIH HHS R01 GM114355NLM NIH HHS T15 LM007079
6 · The paper itself

Abstract

objectiveUniversal HIV screening programs are costly, labor intensive, and often fail to identify high-risk individuals. Automated risk assessment methods that leverage longitudinal electronic health records (EHRs) could catalyze targeted screening programs. Although social and behavioral determinants of health are typically captured in narrative documentation, previous analyses have considered only structured EHR fields. We examined whether natural language processing (NLP) would improve predictive models of HIV diagnosis.

methodsOne hundred eighty-one HIV+ individuals received care at New York Presbyterian Hospital before a confirmatory HIV diagnosis and 543 HIV negative controls were selected using propensity score matching and included in the study cohort. EHR data including demographics, laboratory tests, diagnosis codes, and unstructured notes before HIV diagnosis were extracted for modeling. Three predictive algorithms were developed using machine-learning algorithms: (1) a baseline model with only structured EHR data, (2) baseline plus NLP topics, and (3) baseline plus NLP clinical keywords.

resultsPredictive models demonstrated a range of performance with F measures of 0.59 for the baseline model, 0.63 for the baseline + NLP topic model, and 0.74 for the baseline + NLP keyword model. The baseline + NLP keyword model yielded the highest precision by including keywords including "msm," "unprotected," "hiv," and "methamphetamine," and structured EHR data indicative of additional HIV risk factors.

conclusionsNLP improved the predictive performance of automated HIV risk assessment by extracting terms in clinical text indicative of high-risk behavior. Future studies should explore more advanced techniques for extracting social and behavioral determinants from clinical text.

Indexed as

Decision Support TechniquesElectronic Health RecordsNatural Language ProcessingAdolescentAdultAgedAged, 80 and overAlgorithmsAutomationChildChild, PreschoolCohort StudiesFemaleHIV InfectionsHumansInfant

Identifiers

PMID29084046
PMCPMC5762388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.