ReviewJournal of biopharmaceutical statistics2018
Design, data monitoring, and analysis of clinical trials with co-primary endpoints: A review.
Review in Journal of biopharmaceutical statistics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial.Nature medicine · 2025Trial
- A phase II trial of weekly nab-paclitaxel for progressive and symptomatic desmoid tumors.Nature communications · 2022Trial
- Trial
- Nurse-led multicomponent educational intervention in primary care to reduce fear of falling in older adults: a cluster randomized trial.BMC nursing · 2026Article
- Exact Randomized Two-Stage Phase 2 Clinical Trial Designs for Two Binary Co-Primary Endpoints.Statistics in medicine · 2026Article
- Considerations for Issues of Regression to the Mean and Contextual Effects in Clinical Trials for Pain in Rheumatic Diseases.Arthritis care & research · 2026Review
- Article
- A novel longitudinal rank-sum test for multiple primary endpoints in clinical trials: Applications to neurodegenerative disorders.Statistics in biopharmaceutical research · 2025Article
- Clinical trials for Wolfram syndrome neurodegeneration: Novel design, endpoints, and analysis models.PloS one · 2025Article
- A Vector Theory of Assessing Clinical Trials: An Application to Bioequivalence.Journal of cardiovascular development and disease · 2024Article
- CDC's Hospital-Onset Clostridioides difficile Prevention Framework in a Regional Hospital Network.JAMA network open · 2024Article
- Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities.JAMA network open · 2024Article
- Enhanced supportive care for advanced cancer patients: study protocol for a randomized controlled trial.BMC nursing · 2022Article
- Blinded sample size re-estimation in a comparative diagnostic accuracy study.BMC medical research methodology · 2022Article
- Review of pragmatic trials found that multiple primary outcomes are common but so too are discrepancies between protocols and final reports.Journal of clinical epidemiology · 2022Review
- A Composite Endpoint for Treatment Benefit According to Patient Preference.Statistics in biopharmaceutical research · 2022Article
- Article
- Interim Monitoring for Futility in Clinical Trials with Two Co-primary Endpoints Using Prediction.Statistics in biopharmaceutical research · 2020Article
- Comparison of three sample size calculation methods for non-inferiority vaccine trials with multiple continuous co-primary endpoints.Human vaccines & immunotherapeutics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We review the design, data monitoring, and analyses of clinical trials with co-primary endpoints. Recently developed methods for fixed-sample and group-sequential settings are described. Practical considerations are discussed, and guidance for the application of these methods is provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.