Evidence map›Paper›PMID 29083540›Full record

ArticleAdvanced healthcare materials2017

Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses.

Yoon Kyung Kim, Shu-Hui Chu, Jessica Y Hsieh, Cody M Kamoku, Andrea J Tenner, Wendy F Liu, Szu-Wen Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoon Kyung KimDepartment of Chemical Engineering & Materials Science, University of California, Irvine, CA, 92697, USA.
Shu-Hui ChuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA.
Jessica Y HsiehDepartment of Biomedical Engineering, University of California, Irvine, CA, 92697, USA.
Cody M KamokuDepartment of Chemical Engineering & Materials Science, University of California, Irvine, CA, 92697, USA.
Andrea J TennerDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, 92697, USA.
Wendy F LiuDepartment of Chemical Engineering & Materials Science, University of California, Irvine, CA, 92697, USA.
Szu-Wen WangDepartment of Chemical Engineering & Materials Science, University of California, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0001-7398-0220
University of California, Irvine · US

Funding

Engineering Biomaterials to Exert Molecular Control of Immune Cell FunctionDP2DE023319 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2012 to 2012
$2.3M
Training Program in Cardiovascular Applied Research and EntrepreneurshipT32HL116270 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUGHES, CHRISTOPHER C. W. · 2013 to 2022
$1.6M
Modulation of Immune Responses to Implanted Surfaces Using Engineered ECM DomainsR21EB022240 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI WANG, SZU-WEN · 2017 to 2018
$422k
NHLBI NIH HHS T32 HL116270NIBIB NIH HHS R21 EB022240NIDCR NIH HHS DP2 DE023319
6 · The paper itself

Abstract

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an inhibitory receptor broadly expressed on immune cells, with its ligands residing within the extracellular matrix protein collagen. In this study, surfaces are modified with a LAIR-1 ligand peptide (LP), and it is observed that macrophages cultured on LAIR-1 LP-conjugated surfaces exhibit significantly reduced secretion of inflammatory cytokines in response to proinflammatory stimuli that reflect an injured environment. These downregulated mediators include TNF-α, MIP-1α, MIP-1β, MIP-2, RANTES, and MIG. Knockdown of LAIR-1 using siRNA abrogates this inhibition of cytokine secretion, supporting the specificity of the inhibitory effect to this receptor. These results are the first to demonstrate that integration of LAIR-1 ligands with biomaterials could suppress inflammatory responses.

Indexed as

Biocompatible MaterialsChemokine CCL3Chemokine CCL4Chemokine CCL5Chemokine CXCL2Chemokine CXCL9Gene Expression RegulationHumansLigandsMacrophagesPeptidesProtein BindingReceptors, ImmunologicTumor Necrosis Factor-alphaBiocompatible MaterialsChemokine CCL3Chemokine CCL4Chemokine CCL5Chemokine CXCL2Chemokine CXCL9leukocyte-associated immunoglobulin-like receptor 1LigandsPeptidesReceptors, ImmunologicTumor Necrosis Factor-alphacollagen peptidesimmunomodulatory biomaterialsinflammationLAIR-1macrophages

Identifiers

PMID29083540
PMCPMC5792650
OpenAlexW2766427747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.