ArticleNature chemical biology2018
PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides.
Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Acyltransferases that Modify Cell Surface Polymers Across the Membrane.Biochemistry · 2025Review
- The active site of the SGNH hydrolase-like fold proteins: Nucleophile-oxyanion (Nuc-Oxy) and Acid-Base zones.Current research in structural biology · 2024Article
- Mechanism of D-alanine transfer to teichoic acids shows how bacteria acylate cell envelope polymers.Nature microbiology · 2023Article
- The SGNH hydrolase family: a template for carbohydrate diversity.Glycobiology · 2022Review
- Identification of critical residues of O-antigen-modifying O-acetyltransferase B (OacB) of Shigella flexneri.BMC molecular and cell biology · 2022Article
- Article
- TheMicroorganisms · 2020Review
- Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A.Nature communications · 2020Article
- Molecular Mechanism of Polysaccharide Acetylation by the Arabidopsis XylanThe Plant cell · 2020Article
- Bacterial biopolymers: from pathogenesis to advanced materials.Nature reviews. Microbiology · 2020Review
- YqfB protein from Escherichia coli: an atypical amidohydrolase active towards NScientific reports · 2020Article
- Identification of the Clostridial cellulose synthase and characterization of the cognate glycosyl hydrolase, CcsZ.PloS one · 2020Article
- Pyruvate Substitutions on Glycoconjugates.International journal of molecular sciences · 2019Review
- Peptidoglycan O-Acetylation as a Virulence Factor: Its Effect on Lysozyme in the Innate Immune System.Antibiotics (Basel, Switzerland) · 2019Review
- Synthesis of O-1- O-6 Substituted Positional Isomers of d-Glucose-Thioether Ligands and Their Ruthenium Polypyridyl Conjugates.The Journal of organic chemistry · 2018Article
- Article
- Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation.Frontiers in microbiology · 2018Review
- New Insights Into Wall PolysaccharideFrontiers in plant science · 2018Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
O-Acetylation of the secondary cell wall polysaccharides (SCWP) of the Bacillus cereus group of pathogens, which includes Bacillus anthracis, is essential for the proper attachment of surface-layer (S-layer) proteins to their cell walls. Using a variety of pseudosubstrates and a chemically synthesized analog of SCWP, we report here the identification of PatB1 as a SCWP O-acetyltransferase in Bacillus cereus. Additionally, we report the crystal structure of PatB1, which provides detailed insights into the mechanism of this enzyme and defines a novel subfamily of the SGNH family of esterases and lipases. We propose a model for the O-acetylation of SCWP requiring the translocation of acetyl groups from a cytoplasmic source across the plasma membrane by PatA1 and PatA2 for their transfer to SCWP by PatB1.
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