Evidence map›Paper›PMID 29083408›Full record

ArticleNature genetics2017

Exome-wide association study of plasma lipids in >300,000 individuals.

Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves and 222 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 7 pooled it
44.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 7 syntheses or guidelines pooled it, 589 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Article
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  14. Review
  15. Article
  16. Review
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266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

232 authors at 20 institutions in 24 countries.

Dajiang J LiuDepartment of Public Health Sciences, Institute of Personalized Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Haojie YuDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Xiao WangCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Danish SaleheenMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Connor EmdinProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Dewan AlamICDDR, B, Dhaka, Bangladesh.
Alexessander Couto AlvesImperial College London, London, UK.
Philippe AmouyelUniversité Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-related Diseases, Lille, France.
Emanuele Di AngelantonioMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dominique ArveilerDepartment of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France.
Themistocles L AssimesVA Palo Alto Health Care System, Palo Alto, California, USA.
Paul L AuerZilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Usman BaberCardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Lia E BangDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Marianne BennDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jette Bork-JensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, New York, USA.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Morris BrownClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Fabio BusoneroIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Y Eugene ChenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Departments of Pediatrics and Medicine, Los Angeles, California, USA.
Rajiv ChowdhuryMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Cramer ChristensenMedical Department, Lillebaelt Hospital, Vejle, Denmark.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
John M ConnellMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Scott M DamrauerCorporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Anna DominiczakBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Marie-Pierre DubéMontreal Heart Institute, Montreal, Quebec, Canada.
Tapani EbelingDepartment of Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland.
Gudny EiriksdottirThe Icelandic Heart Association, Kopavogur, Iceland.
Tõnu EskoProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Marco FerrarioResearch Centre in Epidemiology and Preventive Medicine-EPIMED, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Jean FerrieresDepartment of Epidemiology, UMR 1027-INSERM, Toulouse University-CHU Toulouse, Toulouse, France.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Myriam FornageInstitute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Lars G FritscheCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Philippe FrossardCenter for Non-Communicable Diseases, Karachi, Pakistan.
Valentin FusterCardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Santhi K GaneshDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wei GaoDepartment of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China.
Melissa E GarciaNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Christian GiegerGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mark O GoodarziDepartments of Medicine and of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Harald GrallertGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology, Clinical Research Centre, Lund University, Malmö, Sweden.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Vilmundur GudnasonThe Icelandic Heart Association, Kopavogur, Iceland.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Joel N HirschhornProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Oddgeir L HolmenDepartment of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway.
Jennifer HuffmanMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Kristian HveemK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Sehrish JabeenCenter for Non-Communicable Diseases, Karachi, Pakistan.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Johanna JakobsdottirThe Icelandic Heart Association, Kopavogur, Iceland.
Marjo-Riitta JarvelinImperial College London, London, UK.
Gorm B JensenThe Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark.
Marit E JørgensenSteno Diabetes Center, Gentofte, Denmark.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Johanne M JustesenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pia R KamstrupDepartment of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Frank KeeUKCRC Centre of Excellence for Public Health, Queens University, Belfast, UK.
Amit V KheraProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Derek KlarinProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Heikki A KoistinenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital NHS Trust, Southall, UK.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Kari KuulasmaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Timo LakkaDepartment of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Anne LangstedDepartment of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Torsten LauritzenDepartment of Public Health, Section of General Practice, University of Aarhus, Aarhus, Denmark.
David C M LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Li An LinInstitute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Allan LinnebergDepartment of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, New York, USA.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, New York, USA.
Xiangfeng LuDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Anders MalarstigCardiovascular Genetics and Genomics Group, Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Alisa K ManningProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Pekka MäntyselkäUnit of Primary Health Care, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nicholas G D MascaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Andrea MaschioIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
James B MeigsProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Olle MelanderDepartment of Clinical Sciences, University Hospital Malmo Clinical Research Center, Lund University, Malmo, Sweden.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Antonella MulasIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Martina Müller-NurasyidInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Matt J NevilleOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jonas B NielsenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-6654-2852
Sune F NielsenDepartment of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Børge G NordestgaardDepartment of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Jose M OrdovasDepartment of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Investigation, Madrid, Spain.
Roxana MehranCardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christoper J O'DonnellMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Marju Orho-MelanderDepartment of Clinical Sciences, University Hospital Malmo Clinical Research Center, Lund University, Malmo, Sweden.
Cliona M MolonyGenetics, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
Pieter MuntendamG3 Pharmaceuticals, Lexington, Massachusetts, USA.
Sandosh PadmanabhanBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Colin N A PalmerMedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Aniruddh P PatelProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Markus PerolaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Annette PetersGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Charlotta PisingerResearch Center for Prevention and Health, Copenhagen, Denmark.
Giorgio PistisIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, London, UK.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Daniel J RaderDepartments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Dermot F ReillyGenetics, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
John D RiouxMontreal Heart Institute, Montreal, Quebec, Canada.
Neil R RobertsonWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Dan M RodenDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Departments of Pediatrics and Medicine, Los Angeles, California, USA.
Igor RudanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Veikko SalomaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Serena SannaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Naveed SattarBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Raquel S SevillaImaging, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
Christian M ShafferDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Xueling SimCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Suthesh SivapalaratnamDepartment of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Albert V SmithThe Icelandic Heart Association, Kopavogur, Iceland.
Blair H SmithDivision of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Sangeetha SomayajulaScientific Informatics, Merck Sharp & Dohme Corporation, Kenilworth, New Jersey, USA.
Lorraine SouthamWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Elizabeth K SpeliotesDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Kathleen E StirrupsWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nathan StitzielCardiovascular Division, Departments of Medicine and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Konstantin StrauchIBE, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Germany.
Heather M StringhamCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Hayato TadaDivision of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Alan R TallDepartment of Medicine, Division of Molecular Medicine, Columbia University, New York, New York, USA.
Hua TangDepartment of Genetics, Stanford University School of Medicine, Stanford, California, USA.
Jean-Claude TardifMontreal Heart Institute, Montreal, Quebec, Canada.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Departments of Pediatrics and Medicine, Los Angeles, California, USA.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Philip S TsaoVA Palo Alto Health Care System, Palo Alto, California, USA.
Jaakko TuomilehtoChronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Anne Tybjaerg-HansenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Natalie R van ZuydamWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Anette VarboDepartment of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Jarmo VirtamoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nan WangDepartment of Medicine, Division of Molecular Medicine, Columbia University, New York, New York, USA.
Nick J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Helen R WarrenClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Peter E WeekeDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Joshua WeinstockCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Jennifer WesselDepartment of Epidemiology, Indiana University Fairbanks School of Public Health, Indianapolis, Indiana, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Peter W F WilsonAtlanta VA Medical Center, Decatur, Georgia, USA.
Ming XuDepartment of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Robin YoungMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Eleftheria ZegginiWellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
He ZhangDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Neil S ZhengYale College, Yale University, New Haven, Connecticut, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Wei ZhouDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Yanhua ZhouDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Charge Diabetes Working Group
EPIC-InterAct Consortium
EPIC-CVD Consortium
GOLD Consortium
VA Million Veteran Program
Joanna M M HowsonMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Chad A CowanDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.
Goncalo AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Kiran MusunuruCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0002-6724-032X
University of Copenhagen · DKBroad Institute · USUniversity of Cambridge · GBQueen Mary University of London · GBUniversity of Michigan · USCentre for Human Genetics · GBBrigham and Women's Hospital · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPeking University · CNUniversity of Eastern Finland · FIHarvard University · USLund University · SEMontreal Heart Institute · CAUniversity of Iceland · ISBoston University · USInserm · FRUniversity of Exeter · GBBaylor College of Medicine · USCopenhagen University Hospital · DKFinnish Institute for Health and Welfare · FI

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
British Heart Foundation CH/12/2/29428British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194British Heart Foundation RG/14/5/30893British Heart Foundation RG/16/4/32218Medical Research Council G0600237Medical Research Council G0601261Medical Research Council G9521010Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_U127561128Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/K026992/1Medical Research Council MR/L003120/1Medical Research Council MR/M009203/1Medical Research Council MR/N005813/1Medical Research Council MR/P013880/1Medical Research Council MR/P02811X/1NCATS NIH HHS KL2 TR001100NCATS NIH HHS UL1 TR001881NCI NIH HHS UM1 CA182913NHGRI NIH HHS R01 HG008983NHGRI NIH HHS T32 HG000040NHLBI NIH HHS K01 HL125751NHLBI NIH HHS K99 HL094535NHLBI NIH HHS R00 HL094535NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL117491NHLBI NIH HHS R01 HL118567NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL122684NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL129778NHLBI NIH HHS R21 HL121422NHLBI NIH HHS U01 HL120393NIDA NIH HHS R01 DA037904NIDA NIH HHS R21 DA040177NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK078616NIGMS NIH HHS U54 GM115428NIH HHS S10 OD018522NIH HHS S10 OD020069Wellcome Trust
6 · The paper itself

Abstract

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.

Indexed as

Genetic VariationCoronary Artery DiseaseDiabetes Mellitus, Type 2ExomeGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansLipidsMacular DegenerationPhenotypeRisk FactorsLipids

Identifiers

PMID29083408
PMCPMC5709146
OpenAlexW2767038995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.