SynthesisNature genetics2017
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
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99citing papers in PubMed, 6 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 6 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.Genome biology · 2022Pooled it
- The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.Nature communications · 2022Pooled it
- Pooled it
- Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.Nature genetics · 2020Pooled it
- Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.PLoS genetics · 2020Pooled it
- Genomic study of maternal lipid traits in early pregnancy concurs with four known adult lipid loci.Journal of clinical lipidologyPooled it
- Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods.Nature communications · 2022Trial
- Chinese Population-Wide Lipid Trajectories From Age 20 to 85 Years: Sex- and Adiposity-Specific Patterns.JACC. Asia · 2026Article
- Improving Polygenic Risk Prediction for Atherosclerotic Cardiovascular Disease in East Asian Populations.JACC. Asia · 2026Review
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations.Nature genetics · 2026Article
- Molecular characterization of a rare heterozygousFrontiers in genetics · 2026Article
- Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities.Nature medicine · 2025Article
- Directly Measuring Atherogenic Lipoprotein Kinetics in Zebrafish With the Photoconvertible LipoTimer Reporter.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Metabolic diseases in the East Asian populations.Nature reviews. Gastroenterology & hepatology · 2025Review
- The breadth and impact of the Global Lipids Genetics Consortium.Current opinion in lipidology · 2025Review
- Assessment of six surrogate insulin resistance indexes for predicting hypertension risk in rural Chinese adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis.Genome biology · 2025Article
- Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study.Cardiovascular diabetology · 2025Observational
- Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
68 authors at 20 institutions in 7 countries.
Xiangfeng LuDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0003-4088-2338
Gina M PelosoProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Dajiang J LiuDepartment of Public Health Sciences, Institute of Personalized Medicine, Penn State University, University Park, Pennsylvania, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
He ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wei ZhouDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Jun LiMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Clara Sze-Man TangDepartment of Surgery, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Dr. Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, Hong Kong, China.ORCID http://orcid.org/0000-0003-0265-2638
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6608-2051
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Los Angeles, California, USA.
Ming XuDepartment of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China.
Cassandra N SpracklenDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Yang ChenCenter for Genomic and Personalized Medicine, Medical Scientific Research Center and Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Xuezhen LiuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Liang SunKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Laiyuan WangDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yao HuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Kuai YuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Yiqin WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Chloe Yu Yan CheungDepartment of Medicine, the University of Hong Kong, Hong Kong, China.
Feijie WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Jianfeng HuangDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qiao FanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Shufeng ChenDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jinxiu ShiDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.
Xueli YangDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wanting ZhaoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Stacey Shawn ChernyDepartment of Psychiatry, the University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-0269-3352
Meian HeMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Alan B FeranilUSC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
Linda S AdairDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0001-5322-4188
Shufa DuDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Rohit VarmaUSC Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Los Angeles, California, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Karen Siu Ling LamDepartment of Medicine, the University of Hong Kong, Hong Kong, China.
Tien Yin WongDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
Santhi K GaneshDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Zengnan MoCenter for Genomic and Personalized Medicine, Medical Scientific Research Center and Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Lars G FritscheHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Jonas Bille NielsenDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-6654-2852
Hung-Fat TseDepartment of Medicine, the University of Hong Kong, Hong Kong, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Y Eugene ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID http://orcid.org/0000-0003-1226-070X
E Shyong TaiDuke-National University of Singapore Graduate Medical School, Singapore, Singapore.
Wei GaoDepartment of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China.
Wei HuangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.
Goncalo AbecasisDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
GLGC Consortium
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0002-6724-032X
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID http://orcid.org/0000-0001-6721-153X
Tangchun WuMOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Pak Chung ShamDepartment of Psychiatry, the University of Hong Kong, Hong Kong, China.
Dongfeng GuDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0002-2781-7825
Cristen J WillerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0001-5645-4966
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CNChinese University of Hong Kong · HKUniversity of North Carolina at Chapel Hill · USHuazhong University of Science and Technology · CNUniversity of Michigan · USGuangxi Medical University · CNNational University of Singapore · SGPeking University · CNVanderbilt University · USAgency for Science, Technology and Research · SGBroad Institute · USChinese National Human Genome Center · CNNorwegian University of Science and Technology · NOFoundation University · PHMichigan Medicine · USPennsylvania State University · USRenji Hospital · CNSingapore National Eye Center · SGTaichung Veterans General Hospital · TW
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MUsing Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4MEmergence of Cardiometabolic Risk Across the Lifecycle in ChinaR01HL108427 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY · 2012 to 2015
$2.7MTransition to a Western diet and cardiometabolic risk: biomarkers derived from the microbiomeR01DK104371 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY · 2015 to 2018
$2.5MNutrition-Related NCD Prevention Training in ChinaD43TW009077 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2011 to 2015
$1.1MDiscovering lipoprotein lipase pathway variants that protect against CHDK01HL125751 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PELOSO, GINA MARIE · 2015 to 2018
$562kFIC NIH HHS D43 TW009077NCATS NIH HHS UL1 TR001881NHLBI NIH HHS K01 HL125751NHLBI NIH HHS R01 HL108427NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R35 HL135824NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK104371
Abstract
Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations. After a meta-analysis including >300,000 European samples, we identified an additional nine novel loci. Sixteen genes were identified by protein-altering variants in both East Asians and Europeans, and thus are likely to be functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.
Indexed as
Genetic VariationAsia, EasternAsian PeopleCoronary Artery DiseaseEuropeExomeGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLipid MetabolismLipidsWhite PeopleLipids
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