SynthesisNature genetics2017
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 11 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 11 pooled it
31.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
300 citing papers in PubMed, 11 syntheses or guidelines pooled it, 556 citations in OpenAlex.
- 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.Nature communications · 2025Pooled it
- Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis.Nature communications · 2025Pooled it
- Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.Allergy · 2025Pooled it
- Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.European journal of preventive cardiology · 2024Pooled it
- A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity.Journal of translational medicine · 2024Pooled it
- Pooled it
- Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder.Scientific reports · 2022Pooled it
- A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci.The Journal of allergy and clinical immunology · 2022Pooled it
- Effects ofFrontiers in genetics · 2022Pooled it
- Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.Nature communications · 2021Pooled it
- Shared DNA methylation signatures in childhood allergy: The MeDALL study.The Journal of allergy and clinical immunology · 2021Pooled it
- Immune shifts in inflammatory skin diseases.JID innovations : skin science from molecules to population health · 2026Review
- Cross-scale genetic analysis prioritizes shared regulatory variation, cell-type contributions, co-expression programs, and exon-level patterns in atopic dermatitis and asthma.Functional & integrative genomics · 2026Article
- Dynamic CD4+ T Cell Genetics Identifies Candidate Therapeutic Targets for Allergic Rhinitis: Mendelian Randomization with Exploratory Single-Cell Contextualization.Biomedicines · 2026Article
- Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics.Nature genetics · 2026Article
- The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait.Pulmonary therapy · 2026Review
- Post-genome-wide association study variant-to-function challenges in asthma research.The Journal of allergy and clinical immunology · 2026Review
- Child characteristics, household, and home environmental factors associated with eczema: a cross-sectional study.European journal of pediatrics · 2026Article
- A New Mouse Model for Ozone Health Effects Research.Environmental health perspectives · 2026Article
- Preparation and pharmacological study ofBiomedical reports · 2026Article
240 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
70 authors at 19 institutions in 7 countries.
Manuel A FerreiraGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-9059-1825
Judith M VonkEpidemiology, University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.
Hansjörg BaurechtDepartment of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Ingo MarenholzMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Chao TianResearch, 23andMe, Mountain View, California, USA.
Joshua D HoffmanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Quinta HelmerDepartment of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands.
Annika TillanderDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jenny van DongenDepartment of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands.
Yi LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Franz RüschendorfMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0001-5640-810X
Jorge Esparza-GordilloMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Chris W MedwayMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Edward MountjoyMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-0626-1821
Kimberley BurrowsMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Oliver HummelMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Sarah GroscheMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Ben M BrumptonMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
John S WitteEpidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Jouke-Jan HottengaDepartment of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands.
Jie ZhengMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Elke RodríguezDepartment of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Melanie HotzeDepartment of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-1530-5811
Joana A RevezGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jonathan BeesleyGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Melanie C MathesonMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Shyamali C DharmageMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Lisa M BainGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lars G FritscheK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Maiken E GabrielsenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Brunilda BalliuDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
23andMe Research Team
AAGC collaborators
BIOS consortium
LifeLines Cohort Study
Jonas B NielsenDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-6654-2852
Wei ZhouDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Arnulf LanghammerHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Oddgeir L HolmenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Mari LøsetK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Gonçalo R AbecasisK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Cristen J WillerK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0001-5645-4966
Andreas ArnoldClinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
Carsten O SchmidtInstitute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany.
Philip J ThompsonInstitute for Respiratory Health, Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands, Western Australia, Australia.
Nicholas G MartinGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
David L DuffyGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Natalija NovakDepartment of Dermatology and Allergology, University Hospital Bonn, Bonn, Germany.
Holger SchulzInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Stefan KarraschInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ronald B MellesDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.
David A HindsResearch, 23andMe, Mountain View, California, USA.
Norbert HübnerMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Stephan WeidingerDepartment of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Rick JansenDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3333-6737
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, California, USA.ORCID http://orcid.org/0000-0002-5829-8191
Young-Ae LeeMax Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije University, Amsterdam, the Netherlands.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1045-1898
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.
Lavinia PaternosterMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Norwegian University of Science and Technology · NOMax Delbrück Center · DEQIMR Berghofer Medical Research Institute · AUTinbergen Institute · NLKaiser Permanente · USThe University of Melbourne · AUUniversity of California, San Francisco · US23andMe (United States) · USHelmholtz Zentrum München · DEKarolinska Institutet · SEUniversity Medical Center Groningen · NLUniversity of Bristol · GBKarolinska University Hospital · SEThe University of Western Australia · AUUniversity Hospital Schleswig-Holstein · DEChristian-Albrechts-Universität zu Kiel · DEUniversitätsmedizin Greifswald · DEUniversity Hospital Bonn · DEUniversity of Michigan · US
Funding
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5MEuropean Research Council 230374Medical Research Council MC_PC_12028Medical Research Council MC_QA137853Medical Research Council MC_UU_12013/1Medical Research Council MR/J012165/1NCI NIH HHS R25 CA112355Wellcome Trust 102215
Abstract
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS; n = 360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P < 3 × 10
Indexed as
AsthmaEczemaGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypersensitivityPhenotypePolymorphism, Single NucleotideRhinitis, Allergic, SeasonalRisk Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.