ArticleNature genetics2017
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
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Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma.Aging cell · 2025Article
- Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque.Molecular ecology · 2025Article
- The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.Nature genetics · 2025Review
- Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons.Cell genomics · 2024Article
- Current advances in primate genomics: novel approaches for understanding evolution and disease.Nature reviews. Genetics · 2023Review
- The evolution of the human DNA replication timing program.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The identification of retro-DNAs in primate genomes as DNA transposons mobilizing via retrotransposition.F1000Research · 2023Article
- A causal association of ANKRD37 with human hippocampal volume.Molecular psychiatry · 2022Article
- Epigenetic clock and methylation studies in vervet monkeys.GeroScience · 2022Article
- Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse.Mediators of inflammation · 2022Article
- Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet.BMC genomics · 2021Article
- Where Are the Disease-Associated eQTLs?Trends in genetics : TIG · 2021Review
- Gene expression variability in human and chimpanzee populations share common determinants.eLife · 2020Article
- Broadening primate genomics: new insights into the ecology and evolution of primate gene regulation.Current opinion in genetics & development · 2020Review
- Prime time for primate functional genomics.Current opinion in genetics & development · 2020Review
- Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus).Scientific reports · 2020Article
- Transcriptomic Analysis of Cell-free Fetal RNA in the Amniotic Fluid of Vervet Monkeys (Comparative medicine · 2020Article
- Insight into genetic regulation of miRNA in mouse brain.BMC genomics · 2019Article
- Transcription of PIK3CD in human brain and schizophrenia: regulation by proinflammatory cytokines.Human molecular genetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 13 institutions in 5 countries.
Anna J JasinskaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-1897-4570
Ivette ZelayaInterdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, California, USA.
Susan K ServiceCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Christine B PetersonDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID http://orcid.org/0000-0003-3316-0468
Rita M CantorCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Oi-Wa ChoiCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Joseph DeYoungCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Eleazar EskinDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Lynn A FairbanksCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Scott FearsCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Allison E FurtererInterdepartmental Graduate Program in Neuroscience, University of California, Los Angeles, Los Angeles, California, USA.
Yu S HuangCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Vasily RamenskyCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Christopher A SchmittCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-2143-9226
Hannes SvardalWellcome Trust Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-7866-7313
Matthew J JorgensenDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jay R KaplanDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Diego VillarUniversity of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.
Bronwen L AkenEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-3032-4095
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-3897-7955
Rishi NagEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0001-6399-3773
Emily S WongEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0003-0315-2942
John BlangeroSouth Texas Diabetes and Obesity Institute, UTHSCSA/UTRGV, Brownsville, Texas, USA.
Thomas D DyerSouth Texas Diabetes and Obesity Institute, UTHSCSA/UTRGV, Brownsville, Texas, USA.
Marina BogomolovFaculty of Industrial Engineering and Management, Technion, Haifa, Israel.
Yoav BenjaminiDepartment of Statistics and Operation Research, Tel Aviv University, Tel Aviv, Israel.
George M WeinstockJackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Ken DewarDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Chiara SabattiDepartment of Biomedical Data Science, Stanford University, Stanford, California, USA.
Richard K WilsonMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
J David JentschDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Wesley WarrenMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
Giovanni CoppolaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-2105-1061
Roger P WoodsDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Nelson B FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-3586-6587
University of California, Los Angeles · USEuropean Bioinformatics Institute · GBJames S. McDonnell Foundation · USThe University of Texas Rio Grande Valley · USWake Forest University · USJackson Laboratory · USMcGill University · CAStanford University · USTechnion – Israel Institute of Technology · ILTel Aviv University · ILThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GBWellcome Sanger Institute · GB
Funding
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI ROBAKIS, NIKOLAOS K · 1985 to 2019
$37.9MQUANTITATIVE ANALYSIS OF MICROVASCULAR CHANGES IN THE AGING BRAINP01AG002219 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI HAROUTUNIAN, VAHRAM · 1985 to 2009
$19.2MWhite Matter Abnormalities in SchizophreniaP50MH066392 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI O'DONOVAN, MICHAEL J · 2002 to 2012
$18.6MVervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6MProject 5: In vivo measurement of GABA transmission in healthy controls & subjectP50MH084053 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEWIS, DAVID A · 2008 to 2012
$11.5MInternational Cohort Collection for Bipolar DisorderR01MH085542 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SMOLLER, JORDAN W · 2008 to 2012
$10.7MIntegrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4MVervet Monkey (Cercopithecus Aethiops) Genetic MapR01RR016300 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2002 to 2011
$6.3MVERVET RESEARCH COLONY AS A BIOMEDICAL RESOURCE: AIDSP40RR019963 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAPLAN, JAY ROSS · 2005 to 2011
$6.2MGenetics Association in Schizophrenia and Other DisordersR37MH057881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE · 2013 to 2022
$5.4MIdentification and Characterization of Asymmetrically-Expressed GenesR37MH060233 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2006 to 2014
$5.3MTranslational Methods/Facilities Core (TMF - Core) (8 of 8)PL1NS062410 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EVANS, CHRISTOPHER J. · 2007 to 2011
$4.6MNCRR NIH HHS P40 RR019963NCRR NIH HHS R01 RR016300NIA NIH HHS P01 AG002219NIA NIH HHS P50 AG005138NIDCR NIH HHS UL1 DE019580NIH HHS P40 OD010965NIH HHS R01 OD010980NIMH NIH HHS HHSN271201300031CNIMH NIH HHS P50 MH066392NIMH NIH HHS P50 MH084053NIMH NIH HHS R01 MH075916NIMH NIH HHS R01 MH080405NIMH NIH HHS R01 MH085542NIMH NIH HHS R01 MH093725NIMH NIH HHS R01 MH097276NIMH NIH HHS R01 MH101782NIMH NIH HHS R37 MH057881NIMH NIH HHS R37 MH060233NIMH NIH HHS RL1 MH083270NIMH NIH HHS T32 MH073526NINDS NIH HHS P30 NS062691NINDS NIH HHS PL1 NS062410Wellcome Trust 108749
Abstract
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
Indexed as
Gene Expression ProfilingGenetic VariationAnimalsBrainChlorocebus aethiopsGenome-Wide Association StudyGenotypeHumansPhenotypePolymorphism, Single NucleotideQuantitative Trait Loci
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