Evidence map›Paper›PMID 29083404›Full record

ArticleNature genetics2017

Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.

Hannes Svardal, Anna J Jasinska, Cristian Apetrei, Giovanni Coppola, Yu Huang, Christopher A Schmitt, Beatrice Jacquelin, Vasily Ramensky, Michaela Müller-Trutwin, Martin Antonio and 8 more

Erratum issuedAbstract read
In one paragraph

Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 136 citations in OpenAlex.

  1. Clades, Grades, and the Genus Problem: A Case for Revising Hominin Taxonomy.American journal of biological anthropology · 2026
    Review
  2. Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The first complete mitochondrial genome ofFrontiers in genetics · 2025
    Article
  11. Article
  12. Article
  13. Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Host-Parasite Coevolution in Primates.Life (Basel, Switzerland) · 2023
    Review
  18. Genes and sites under adaptation at the phylogenetic scale also exhibit adaptation at the population-genetic scale.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 10 countries.

Hannes SvardalGregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Vienna, Austria.
Anna J JasinskaCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0002-1897-4570
Cristian ApetreiCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Giovanni CoppolaCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-2105-1061
Yu HuangState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Christopher A SchmittDepartment of Anthropology, Boston University, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0003-2143-9226
Beatrice JacquelinInstitut Pasteur, Unité HIPER, Paris, France.
Vasily RamenskyCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Michaela Müller-TrutwinInstitut Pasteur, Unité HIPER, Paris, France.
Martin AntonioMedical Research Council (MRC), The Gambia Unit, The Gambia.
George WeinstockJackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
J Paul GroblerDepartment of Genetics, University of the Free State, Bloemfontein, South Africa.
Ken DewarDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Richard K WilsonJackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Trudy R TurnerDepartment of Genetics, University of the Free State, Bloemfontein, South Africa.
Wesley C WarrenMcDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri, USA.
Nelson B FreimerCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-3586-6587
Magnus NordborgGregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0001-7178-9748
University of California, Los Angeles · USGregor Mendel Institute of Molecular Plant Biology · ATInstitut Pasteur · FRUniversity of the Free State · ZABoston University · USChinese Academy of Sciences · CNJackson Laboratory · USJames S. McDonnell Foundation · USMcGill University · CAMoscow Institute of Physics and Technology · RUMRC Unit the Gambia · GMNationwide Children's Hospital · USUniversity of Pittsburgh · US

Funding

Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4M
Vervet Monkey (Cercopithecus Aethiops) Genetic MapR01RR016300 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2002 to 2011
$6.3M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
Animal Model for Testing SIV Latency Reversal StrategiesR01AI119346 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APETREI, CRISTIAN · 2015 to 2019
$3.4M
Integrated Genetic and Genomic Resources for a Model SystemR01OD010980 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2012
$741k
NCRR NIH HHS R01 RR016300NIAID NIH HHS R01 AI119346NIH HHS R01 OD010980NIH HHS R24 OD010976NINDS NIH HHS P30 NS062691
6 · The paper itself

Abstract

Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV.

Indexed as

Adaptation, PhysiologicalAfricaAnimalsCD4-Positive T-LymphocytesChlorocebus aethiopsGene Expression ProfilingGene OntologyGene Regulatory NetworksGenetic VariationHost-Pathogen InteractionsHybridization, GeneticMacaca mulattaPhylogenySimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSpecies Specificity

Identifiers

PMID29083404
PMCPMC5709169
OpenAlexW2952949211

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.