Evidence map›Paper›PMID 29083403›Full record

ArticleNature methods2017

An objective comparison of cell-tracking algorithms.

Vladimír Ulman, Martin Maška, Klas E G Magnusson, Olaf Ronneberger, Carsten Haubold, Nathalie Harder, Pavel Matula, Petr Matula, David Svoboda, Miroslav Radojevic and 29 more

Abstract read
In one paragraph

Article in Nature methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed.

  1. Article
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  15. Deep Learning Tools for Single Quantum Dot Tracking.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Bayesian Transformers and Higher-Order Graph Matching for Cell Tracking in Serial Tissue Sections.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  20. Article

132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Vladimír UlmanCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-4270-7982
Martin MaškaCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.
Klas E G MagnussonACCESS Linnaeus Centre, KTH Royal Institute of Technology, Stockholm, Sweden.
Olaf RonnebergerComputer Science Department and BIOSS Centre for Biological Signaling Studies University of Freiburg, Frieburg, Germany.
Carsten HauboldHeidelberg Collaboratory for Image Processing, IWR, University of Heidelberg, Heidelberg, Germany.
Nathalie HarderBiomedical Computer Vision Group, Department of Bioinformatics and Functional Genomics, BIOQUANT, IPMB, University of Heidelberg and DKFZ, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6171-6462
Pavel MatulaCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.
Petr MatulaCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.
David SvobodaCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-6074-0164
Miroslav RadojevicBiomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ihor SmalBiomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Karl RohrBiomedical Computer Vision Group, Department of Bioinformatics and Functional Genomics, BIOQUANT, IPMB, University of Heidelberg and DKFZ, Heidelberg, Germany.
Joakim JaldénACCESS Linnaeus Centre, KTH Royal Institute of Technology, Stockholm, Sweden.
Helen M BlauBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
Oleh DzyubachykDivision of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Boudewijn LelieveldtDivision of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Pengdong XiaoInstitute of Molecular and Cell Biology, A*Star, Singapore.ORCID http://orcid.org/0000-0001-5178-2274
Yuexiang LiDepartment of Engineering, University of Nottingham, Nottingham, UK.
Siu-Yeung ChoFaculty of Engineering, University of Nottingham, Ningbo, China.
Alexandre C DufourBioImage Analysis Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-9417-7389
Jean-Christophe Olivo-MarinBioImage Analysis Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0001-6796-0696
Constantino C Reyes-AldasoroResearch Centre in Biomedical Engineering, School of Mathematics, Computer Science and Engineering, City University of London, London, UK.
Jose A Solis-LemusResearch Centre in Biomedical Engineering, School of Mathematics, Computer Science and Engineering, City University of London, London, UK.
Robert BenschComputer Science Department and BIOSS Centre for Biological Signaling Studies University of Freiburg, Frieburg, Germany.ORCID http://orcid.org/0000-0001-8618-3167
Thomas BroxComputer Science Department and BIOSS Centre for Biological Signaling Studies University of Freiburg, Frieburg, Germany.
Johannes StegmaierGroup for Automated Image and Data Analysis, Institute for Applied Computer Science, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Ralf MikutGroup for Automated Image and Data Analysis, Institute for Applied Computer Science, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.ORCID http://orcid.org/0000-0001-9100-5496
Steffen WolfHeidelberg Collaboratory for Image Processing, IWR, University of Heidelberg, Heidelberg, Germany.
Fred A HamprechtHeidelberg Collaboratory for Image Processing, IWR, University of Heidelberg, Heidelberg, Germany.
Tiago Estevesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0003-3407-6436
Pedro Quelhasi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ömer DemirelS3IT, University of Zurich, Zurich, Switzerland.
Lars MalmströmS3IT, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-9885-9312
Florian JugMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Pavel TomancakMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID http://orcid.org/0000-0002-2222-9370
Erik MeijeringBiomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Arrate Muñoz-BarrutiaBioengineering and Aerospace Engineering Department, Universidad Carlos III de Madrid, Getafe, Spain.ORCID http://orcid.org/0000-0002-1573-1661
Michal KozubekCentre for Biomedical Image Analysis, Masaryk University, Brno, Czech Republic.
Carlos Ortiz-de-SolorzanoCIBERONC, IDISNA and Program of Solid Tumors and Biomarkers, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0001-8720-0205

Funding

Stem Cells for Brain and BrawnR01AG020961 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2002 to 2019
$5.0M
NIA NIH HHS R01 AG020961
6 · The paper itself

Abstract

We present a combined report on the results of three editions of the Cell Tracking Challenge, an ongoing initiative aimed at promoting the development and objective evaluation of cell segmentation and tracking algorithms. With 21 participating algorithms and a data repository consisting of 13 data sets from various microscopy modalities, the challenge displays today's state-of-the-art methodology in the field. We analyzed the challenge results using performance measures for segmentation and tracking that rank all participating methods. We also analyzed the performance of all of the algorithms in terms of biological measures and practical usability. Although some methods scored high in all technical aspects, none obtained fully correct solutions. We found that methods that either take prior information into account using learning strategies or analyze cells in a global spatiotemporal video context performed better than other methods under the segmentation and tracking scenarios included in the challenge.

Indexed as

AlgorithmsImage Interpretation, Computer-AssistedBenchmarkingCell LineCell TrackingHumans

Identifiers

PMID29083403
PMCPMC5777536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.