Evidence map›Paper›PMID 29083399›Full record

ArticleNature immunology2017

Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.

Tomasz Maj, Wei Wang, Joel Crespo, Hongjuan Zhang, Weimin Wang, Shuang Wei, Lili Zhao, Linda Vatan, Irene Shao, Wojciech Szeliga and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 443 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
443citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

443 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
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  8. Article
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  11. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
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383 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Tomasz MajDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Wei WangDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Joel CrespoDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Hongjuan ZhangDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Weimin WangDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Shuang WeiDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Lili ZhaoDepartment of Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Linda VatanDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Irene ShaoDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Wojciech SzeligaDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Costas LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
J Rebecca LiuDepartment of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Ilona KryczekDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Weiping ZouDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0001-7952-3549

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Immune Impact on Cancer ChemoresistanceR01CA211016 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2017 to 2021
$3.0M
Immune Regulation in the Microenvironment of Oropharyngeal CancerR01CA171306 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2013 to 2017
$2.8M
Effector T Cell Trafficking in Ovarian CancerR01CA190176 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2015 to 2019
$2.6M
MDSCs in Ovarian CancerR01CA193136 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2015 to 2019
$2.5M
Human Tregs in Ovarian CancerR01CA099985 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2006 to 2014
$1.8M
Hypoxia and Regulatory T cells in CancerR01CA156685 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2011 to 2015
$1.6M
Novel immunosupressive macrophages in human ovarian tumorR01CA123088 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2007 to 2011
$1.4M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA099985NCI NIH HHS R01 CA123088NCI NIH HHS R01 CA156685NCI NIH HHS R01 CA171306NCI NIH HHS R01 CA190176NCI NIH HHS R01 CA193136NCI NIH HHS R01 CA211016
6 · The paper itself

Abstract

Live regulatory T cells (T

Indexed as

5'-NucleotidaseAdenosineAnimalsAntigens, CDApoptosisApyraseB7-H1 AntigenCTLA-4 AntigenFemaleGPI-Linked ProteinsHumansImmune ToleranceInterleukin-10InterleukinsMiceMice, Inbred C57BL5'-NucleotidaseAdenosineAntigens, CDApyraseB7-H1 AntigenCD274 protein, humanCD39 antigenCTLA-4 AntigenCTLA4 protein, humanGPI-Linked ProteinsIL10 protein, humanInterleukin-10interleukin-35, humanInterleukinsNFE2L2 protein, humanNF-E2-Related Factor 2Nt5e protein, mouseOxygenReceptor, Adenosine A2ATransforming Growth Factor beta

Identifiers

PMID29083399
PMCPMC5770150

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.