ArticleJournal of clinical research in pediatric endocrinology2018
Time Trends, Regional Variability and Seasonality Regarding the Incidence of Type 1 Diabetes Mellitus in Romanian Children Aged 0-14 Years, Between 1996 and 2015
Article in Journal of clinical research in pediatric endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Beyond National Averages: Spatial and Temporal Patterns in Type 2 Diabetes Dynamics in Romania-A 10-Year Time Series Study.Clinics and practice · 2026Article
- Unveiling the gut connection: Exploring the link between microbiota and type 1 diabetes onset in pediatric patients.Biomedical reports · 2026Article
- Increasing Contribution of Adolescent Type 1 Diabetes Drives Incidence Rates in Poland: A 40-Year-Long Observational Study.Hormone research in paediatrics · 2026Observational
- Seasonal Variation in Type 1 Diabetes Incidence in Poland: Exploring the Impact of Viral Infections, Including COVID-19.Pediatric diabetes · 2025Article
- Obesity alters metabolic profiles in children with acute pancreatitis, but not disease severity and recurrence: a Romanian cohort study.Archive of clinical cases · 2025Article
- Association of HLA Haplotypes with Autoimmune Pathogenesis in Newly Diagnosed Type 1 Romanian Diabetic Children: A Pilot, Single-Center Cross-Sectional Study.Life (Basel, Switzerland) · 2024Article
- Epidemiological assessment of diabetes mellitus in children of Ukraine during the last 20 years (2002-2021) of peacetime.SAGE open medicine · 2024Article
- Incidence of Childhood Type 1 Diabetes in Beijing During 2011-2020 and Predicted Incidence for 2025-2035: A Multicenter, Hospitalization-Based Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- Variation in the incidence of type 1 diabetes mellitus in children and adolescents by world region and country income group: A scoping review.PLOS global public health · 2022Article
- Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children.Medicina (Kaunas, Lithuania) · 2021Article
- Inverse association between use of broad spectrum penicllin with beta-lactamase inhibitors and prevalence of type 1 diabetes mellitus in Europe.Scientific reports · 2021Article
- Improvement of Platelet Respiration by Cell-Permeable Succinate in Diabetic Patients Treated with Statins.Life (Basel, Switzerland) · 2021Article
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8 authors.
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Abstract
objectiveThe incidence of type 1 diabetes mellitus in children is highly variable in the world. The aim of our study was to: 1) analyze the evolution of the incidence of childhood type 1 diabetes in Romania between 1996 and 2015, and: 2) to search for differences amongst age groups, gender, geographic regions and month of diagnosis.
methodsData on all new cases of type 1 diabetes, aged <15 years, obtained from two independent sources, were included in the study. The statistical methods included modeling of the incidence rates, adjusting for age, sex, calendar year, geographic region and seasonality.
resultsThe study group was composed of 5422 children, with overall completeness of ascertainment estimated at 93.7%. The incidence rate (per 100.000 person-years) rose continuously, from 4.7 [95% confidence interval (CI) 3.9-5.7] in 1996 to 11.0 (95% CI 9.9-12.2) in 2015, by a yearly rate of 5.1%, highest in the youngest and lowest in the oldest children. The mean incidence was significantly higher (p<0.0001) in Transylvania (7.9, 95% CI 7.6-8.3) than in Moldavia (6.5, 95% CI 6.2-6.9) and Muntenia (7.0, 95% CI 6.7-7.3), probably due to differences regarding ethnicity and lifestyle. The monthly incidence showed a sinusoidal pattern, peaking in January and being minimum in June.
conclusionThe incidence of type 1 diabetes mellitus in Romanian children increased continuously during the study period by a rate that, if maintained, would lead to its doubling every 14 years. Important differences were established between geographic regions and seasonality at diagnosis.
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