ArticlePediatric diabetes2018
Handgrip strength is associated with insulin resistance and glucose metabolism in adolescents: Evidence from National Health and Nutrition Examination Survey 2011 to 2014.
Article in Pediatric diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Sex Differences in Grip Strength From Birth to Age 16: A Meta-Analysis.European journal of sport science · 2025Pooled it
- Muscular Fitness and Cardiometabolic Variables in Children and Adolescents: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women.Scientific reports · 2025Trial
- Colocalization and functional analyses identifyAmerican journal of physiology. Endocrinology and metabolism · 2026Article
- Obesity and its relationship with lifestyle behaviors among Kuwaiti adolescents revisited after 15 years: a study protocol.Frontiers in public health · 2026Article
- A methodological study revisiting obesity and lifestyle behaviors of Jordanian adolescents in Amman after 14 years.Frontiers in sports and active living · 2026Article
- Associations Between Handgrip Strength and Markers of Insulin Resistance and Inflammation in Childhood and Adolescence: A Systematic Review With Meta-Analysis.Translational sports medicine · 2026Review
- Physical performance outweighs grip strength in predicting diabetes risk: evidence from a prospective cohort study.Journal of translational medicine · 2025Article
- Association Between Fasting Insulin Levels and Handgrip Strength: A Cross-Sectional Study Using the Korean National Health and Nutrition Examination Survey.Journal of clinical medicine · 2025Article
- Insufficient Muscle Development Level Associated with Serum Zinc, Manganese and Cobalt Levels in Children Aged 6 to 9 Years in Shenzhen, China.Biological trace element research · 2025Article
- Exploring the relationship between grip strength and diabetic nephropathy among U.S. adults with type 2 diabetes mellitus: a cross-sectional NHANES analysis.BMC endocrine disorders · 2025Article
- Prospective association between handgrip strength in childhood and the metabolic syndrome score and insulin resistance indices in adolescence: an analysis based on the Ewha Birth and Growth Study.Epidemiology and health · 2025Article
- The Relationship Between Health Parameters, Body Size, Elements of Lifestyle, and Hand Grip Strength in a Group of Patients with Type 2 Diabetes, Aged 40-98, from Ulaanbaatar, Mongolia.Journal of clinical medicine · 2024Article
- Sex differences in upper and lower strength and their association with body composition among university students.Physical activity and nutrition · 2024Article
- Normative Data of Grip Strength and Pinch Strength in the Indian Population.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2024Article
- Article
- Hand grip strength as a proposed new vital sign of health: a narrative review of evidences.Journal of health, population, and nutrition · 2024Review
- Association between grip strength and albuminuria in the general United States population: NHANES 2011-2014.Frontiers in public health · 2024Article
- Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies have reported that handgrip strength, a measure of muscular fitness, is associated with insulin resistance in children and adolescents, with conflicting results. Further, no studies have examined the association between handgrip strength with 2-hour glucose levels.
objectiveWe tested the association of handgrip strength with measures of insulin resistance (fasting insulin and homeostasis model assessment of insulin resistance [HOMA-IR]) and glucose metabolism (fasting and 2-hour glucose levels) in adolescents from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
methodsThe study included 959 participants aged 12 to 19 years who underwent a handgrip test and a glucose tolerance test. General linear models were used to examine the associations between handgrip strength and the outcome variables.
resultsAfter adjustment for age, race, sex, body mass index, and physical activities, handgrip strength was inversely associated with fasting insulin levels (P = .017) and HOMA-IR (P = .025). Although there was no association between handgrip strength and fasting glucose levels (P = .77), handgrip strength was inversely associated with 2-hour glucose levels (P < .0001). Insulin and 2-hour glucose levels decreased linearly as handgrip strength increased from the bottom quartile to the top quartile (P for trend: .045 for fasting insulin levels and .004 for 2-hour glucose levels).
conclusionsMuscular fitness, measured by handgrip strength, is associated with insulin resistance and glucose metabolism in adolescents, which indicates that increasing muscular fitness may have beneficial effects for early prevention of insulin resistance and type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.