Evidence map›Paper›PMID 29082582›Full record

ArticleAddiction biology2018

Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.

Lynn M Almli, Adriana Lori, Jacquelyn L Meyers, Jaemin Shin, Negar Fani, Adam X Maihofer, Caroline M Nievergelt, Alicia K Smith, Kristina B Mercer, Kimberly Kerley and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lynn M AlmliDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Adriana LoriDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Jacquelyn L MeyersDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Jaemin ShinCenter for Advanced Brain Imaging, Georgia State University/Georgia Institute of Technology, Atlanta, GA, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Adam X MaihoferDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Kristina B MercerDepartment of Human Genetics, Emory University, Atlanta, GA, USA.
Kimberly KerleyDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Jennifer M LeveilleDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Hao FengDepartment of Human Genetics, Emory University, Atlanta, GA, USA.
Duna Abu-AmaraSteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University, New York, NY, USA.
Janine D FlorySteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University, New York, NY, USA.
Rachel YehudaSteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University, New York, NY, USA.
Charles R MarmarSteven and Alexandra Cohen Veterans Center for Posttraumatic Stress and Traumatic Brain Injury, Department of Psychiatry, New York University, New York, NY, USA.
Dewleen G BakerDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Bekh BradleyDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Karen N ConneelyDepartment of Human Genetics, Emory University, Atlanta, GA, USA.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5158-1103

Funding

X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 1985 to 2007
$21.3M
Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
Genetic and estrogen-dependent regulation of the human PAC1R receptor and PTSDR01MH096764 · NIMH · MCLEAN HOSPITAL · PI RESSLER, KERRY J. · 2012 to 2016
$2.1M
Training Program in Human Disease GeneticsT32MH087977 · NIMH · EMORY UNIVERSITY · PI WARREN, STEPHEN T. · 2009 to 2013
$1.3M
Gene-Environment Interaction for Cannabis Use Disorders in Blacks and Whites in the U.S.K01DA037914 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI MEYERS, JACQUELYN LEIGH · 2015 to 2019
$573k
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
Department of Defense W81XWH-09-2-0044Department of Defense W911NF-09-1-0298Howard Hughes Medical InstituteNational Institutes of Drug Abuse K01 DA037914National Institutes of Mental Health T32 MH87977-5NCRR NIH HHS M01 RR000039NIDA NIH HHS K01 DA037914NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH096764NIMH NIH HHS R56 MH071537NIMH NIH HHS T32 MH087977
6 · The paper itself

Abstract

Excessive alcohol use is extremely prevalent in the United States, particularly among trauma-exposed individuals. While several studies have examined genetic influences on alcohol use and related problems, this has not been studied in the context of trauma-exposed populations. We report results from a genome-wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a trauma-exposed cohort. Results indicate a genome-wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2.61 × 10

Indexed as

AdolescentAdultAgedAlcoholismBlack or African AmericanBrainCohort StudiesFemaleGenome-Wide Association StudyGeorgiaHumansMagnetic Resonance ImagingMaleMiddle AgedPolymorphism, Single NucleotideSodium ChannelsSCLT1 protein, humanSodium Channelsalcohol consumptionalcohol use disorderAUDITexpression QTLfMRIgenome-wide association study

Identifiers

PMID29082582
PMCPMC6584945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.