ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2018
Intrapartum group B Streptococcus screening in the labor ward by Xpert® GBS real-time PCR.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Digestive Colonization of the Newborn Children by the Streptococcus of the Group B
Innovative Strategies for Perinatal Infectious Risk Reduction
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Rapid tests for detecting group B streptococcus colonization in pregnant women: A systematic review and meta-analysis of diagnostic accuracy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Pooled it
- Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci.PloS one · 2019Trial
- Time to rethink prevention of neonatal group B streptococcal disease.Seminars in immunopathology · 2026Review
- Intrapartum Molecular Detection of Group BMicroorganisms · 2026Article
- Late-onset group B streptococcal septic arthritis in an afebrile neonate: a case report.Frontiers in pediatrics · 2026Article
- Comparison of qPCR and chromogenic culture methods for rapid detection of group B streptococcus colonization in Vietnamese pregnant women.Practical laboratory medicine · 2024Article
- Performances of two rapid LAMP-based techniques for the intrapartum detection of Group B Streptococcus vaginal colonization.Annals of clinical microbiology and antimicrobials · 2024Article
- Multicenter Performance Evaluation of the RevogeneMolecular diagnosis & therapy · 2023Article
- Inferring longitudinal patterns of group B Streptococcus colonization during pregnancy.iScience · 2023Article
- Evaluation of two rapid commercial assays for detection of Streptococcus agalactiae from vaginal samples.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy.Journal of advanced nursing · 2022Article
- An Application of Real-Time PCR and CDC Protocol May Significantly Reduce the Incidence ofPathogens (Basel, Switzerland) · 2022Article
- Group B Streptococcal Neonatal Meningitis.Clinical microbiology reviews · 2022Review
- Evaluation of Xpert GBS assay and Xpert GBS LB assay for detection of Streptococcus agalactiae.Annals of clinical microbiology and antimicrobials · 2021Article
- 12/111phiA Prophage Domestication Is Associated with Autoaggregation and Increased Ability to Produce Biofilm inMicroorganisms · 2021Article
- Group B Streptococcus Screening Guidelines in Pregnancy: A Critical Review of Compliance.Maternal and child health journal · 2021Review
- American Society for Microbiology Provides 2020 Guidelines for Detection and Identification of Group BJournal of clinical microbiology · 2020Article
- Risk-based maternal group B Streptococcus screening strategy is compatible with the implementation of neonatal early-onset sepsis calculator.Clinical and experimental pediatrics · 2020Article
- Group B Streptococcus detection in pregnant women: comparison of qPCR assay, culture, and the Xpert GBS rapid test.BMC pregnancy and childbirth · 2019Article
- Intrapartum PCR-assay for detection of Group B Streptococci (GBS).European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Group B Streptococcus (GBS) is the leading cause of neonatal infections in industrialized countries. Intrapartum antibiotic prophylaxis (IAP) given to colonized parturients is a key step for the prevention of neonatal early-onset infection. We compared the performances of Xpert® GBS polymerase chain reaction (PCR) (Cepheid, Sunnyvale, CA, USA) as a point-of-care system in labor wards to standard culture for intrapartum GBS detection. Pregnant women with a GBS-positive antenatal screening were prospectively included. A vaginal double swab was collected at the time of delivery for point-of-care Xpert® GBS PCR and GBS culture. A total of 565 pregnant women were included. Valid Xpert® GBS results were obtained for 488 (86.4%) women on the first attempt. Repeat testing improved the PCR success to 516 (91.3%) women. Among the 305 women positive for GBS by culture at delivery, only 238 (78.0%) were positive by Xpert® GBS PCR, cycle thresholds being correlated to culture quantification. Among 260 women negative for GBS culture, 56 (21.5%) were positive by Xpert® GBS PCR, including 50 where IAP was initiated before vaginal sampling. Overall, among the 565 women with GBS antenatal positive culture, only 335 (59.3%) were still positive at delivery whatever the technique used, resulting in unnecessary IAP for 40% of them. This large cohort study comparing intrapartum to antepartum GBS detection provides evidence that (i) Xpert® GBS PCR might be a valuable solution for intrapartum GBS detection compared to culture-based strategies and (ii) laboratory training of non-specialized staff is mandatory to reach the performances required for point-of-care tests.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.