Evidence map›Paper›PMID 29082102›Full record

ArticleBiomedical optics express2017

Custom built nonlinear optical crosslinking (NLO CXL) device capable of producing mechanical stiffening in ex vivo rabbit corneas.

Samantha M Bradford, Eric R Mikula, Dongyul Chai, Donald J Brown, Tibor Juhasz, James V Jester

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Corneal Crosslinking in Refractive Corrections.Translational vision science & technology · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Advances in the diagnosis and treatment of keratoconus.Therapeutic advances in ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samantha M BradfordDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Eric R MikulaDepartment of Ophthalmology, 843 Health Sciences Road, University of California, Irvine, CA, 92697-4390, USA.
Dongyul ChaiDepartment of Ophthalmology, 843 Health Sciences Road, University of California, Irvine, CA, 92697-4390, USA.
Donald J BrownDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
Tibor JuhaszDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
James V JesterDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · US

Funding

Non-linear Optical Collagen Cross-linking (NLO CXL) for Treatment of Keratoconus.R01EY024600 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI JESTER, JAMES V · 2014 to 2024
$3.1M
NEI NIH HHS R01 EY024600
6 · The paper itself

Abstract

The purpose of this study was to develop and test a nonlinear optical device to photoactivate riboflavin to produce spatially controlled collagen crosslinking and mechanical stiffening within the cornea. A nonlinear optical device using a variable numerical aperture objective was built and coupled to a Chameleon femtosecond laser. Ex vivo rabbit eyes were then saturated with riboflavin and scanned with various scanning parameters over a 4 mm area in the central cornea. Effectiveness of NLO CXL was assessed by evaluating corneal collagen auto fluorescence (CAF). To determine mechanical stiffening effects, corneas were removed from the eye and subjected to indentation testing using a 1 mm diameter probe and force transducer. NLO CXL was also compared to standard UVA CXL. The NLO CXL delivery device was able to induce a significant increase in corneal stiffness, comparable to the increase produced by standard UVA CXL.

Indexed as

(170.0170) Medical optics and biotechnology(190.0190) Nonlinear optics

Identifiers

PMID29082102
PMCPMC5654817
OpenAlexW2758091006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.