ArticleBiomedical optics express2017
Millisecond infrared laser pulses depolarize and elicit action potentials on
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.Biomedical optics express · 2026Article
- How spatial temperature gradients modulate infrared stimulation of the ex vivo rat sciatic nerve.Biophysical journal · 2025Article
- Quantifying tissue temperature changes induced by infrared neural stimulation: numerical simulation and MR thermometry.Biomedical optics express · 2024Article
- Single infrared light pulses induce excitatory and inhibitory neuromodulation.Biomedical optics express · 2022Article
- Advantages, Pitfalls, and Developments of All Optical Interrogation Strategies of MicrocircuitsFrontiers in neuroscience · 2022Review
- [Study on the temperature characteristics of fast capacitance in patch clamp experiments].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Spike frequency-dependent inhibition and excitation of neural activity by high-frequency ultrasound.The Journal of general physiology · 2020Article
- Infrared inhibition impacts on locally initiated and propagating action potentials and the downstream synaptic transmission.Neurophotonics · 2020Article
- Thermal damage threshold of neurons during infrared stimulation.Biomedical optics express · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work focuses on the optical stimulation of dorsal root ganglion (DRG) neurons through infrared laser light stimulation. We show that a few millisecond laser pulse at 1875 nm induces a membrane depolarization, which was observed by the patch-clamp technique. This stimulation led to action potentials firing on a minority of neurons beyond an energy threshold. A depolarization without action potential was observed for the majority of DRG neurons, even beyond the action potential energy threshold. The use of ruthenium red, a thermal channel blocker, stops the action potential generation, but has no effects on membrane depolarization. Local temperature measurements reveal that the depolarization amplitude is sensitive to the amplitude of the temperature rise as well as to the time rate of change of temperature, but in a way which may not fully follow a photothermal capacitive mechanism, suggesting that more complex mechanisms are involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.