ArticleBiomedical optics express2017
Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 27 citations in OpenAlex.
- A Reflective Terahertz Point Source Meta-Sensor with Asymmetric Meta-Atoms for High-Sensitivity Bio-Sensing.Biosensors · 2024Article
- Terahertz circular polarization sensing for protein denaturation based on a twisted dual-layer metasurface.Biomedical optics express · 2022Article
- Study on an artificial phenomenon observed in terahertz biological imaging.Biomedical optics express · 2021Article
- Label-free self-referenced sensing of living cells by terahertz metamaterial-based reflection spectroscopy.Biomedical optics express · 2019Article
- Calculated Terahertz Spectra of Glycine Oligopeptide Solutions Confined in Carbon Nanotubes.Polymers · 2019Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aptamer and target molecule binding reaction has been widely applied for construction of aptasensors, most of which are labeled methods. In contrast, terahertz technology proves to be a label-free sensing tool for biomedical applications. We utilize terahertz absorption spectroscopy and molecular dynamics simulation to investigate the variation of binding-induced collective vibration of hydrogen bond network in a mixed solution of MUC1 peptide and anti-MUC1 aptamer. The results show that binding-induced alterations of hydrogen bond numbers could be sensitively reflected by the variation of terahertz absorption coefficients of the mixed solution in a customized fluidic chip. The minimal detectable concentration is determined as 1 pmol/μL, which is approximately equal to the optimal immobilized concentration of aptasensors.
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