Evidence map›Paper›PMID 29082011›Full record

ArticleBMJ global health2017

Predictors of attrition from care at 2 years in a prospective cohort of HIV-infected adults in Tigray, Ethiopia.

Raffaella Bucciardini, Vincenzo Fragola, Teshome Abegaz, Stefano Lucattini, Atakilt Halifom, Eskedar Tadesse, Micheal Berhe, Katherina Pugliese, Luca Fucili, Massimiliano Di Gregorio and 10 more

Abstract read
In one paragraph

Article in BMJ global health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Raffaella BucciardiniIstituto Superiore di Sanità, Rome, Italy.
Vincenzo FragolaIstituto Superiore di Sanità, Rome, Italy.
Teshome AbegazCollege of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Stefano LucattiniIstituto Superiore di Sanità, Rome, Italy.
Atakilt HalifomTigray Regional Health Bureau, Mekelle, Ethiopia.
Eskedar TadesseCollege of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Micheal BerheCollege of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Katherina PuglieseIstituto Superiore di Sanità, Rome, Italy.
Luca FuciliIstituto Superiore di Sanità, Rome, Italy.
Massimiliano Di GregorioIstituto Superiore di Sanità, Rome, Italy.
Marco MirraIstituto Superiore di Sanità, Rome, Italy.
Paola De CastroIstituto Superiore di Sanità, Rome, Italy.
Roberta TerlizziIstituto Superiore di Sanità, Rome, Italy.
Paola TatarelliDepartment of Infectious Diseases, Università degli studi di Genova, Genoa, Italy.
Andrea BinelliIstituto Superiore di Sanità, Rome, Italy.
Teame ZegeyeTigray Regional Health Bureau, Mekelle, Ethiopia.
Michela CampagnoliIstituto Superiore di Sanità, Rome, Italy.
Stefano VellaIstituto Superiore di Sanità, Rome, Italy.
Loko AbrahamCollege of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Hagos GodefayTigray Regional Health Bureau, Mekelle, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEthiopia has experienced rapid expansion of antiretroviral therapy (ART). However, as long-term retention in ART therapy is key for ART effectiveness, determinants of attrition need to be identified so appropriate interventions can be designed.

methodsWe used data from the 'Cohort of African people Starting Antiretroviral therapy' (CASA) project, a prospective study of a cohort of HIV-infected patients who started ART in seven health facilities (HFs). We analysed the data of patients who had started first-line ART between January 2013 and December 2014. The Kaplan-Meier method was used to estimate the probability of retention at different time points. The Cox proportional hazards model was used to identify factors associated with attrition.

resultsA total of 1198 patients were included in the study. Kaplan-Meier estimates of retention in care were 83.9%, 82.1% and 79.8% at 12, 18 and 24 months after starting ART, respectively. Attrition was mainly due to loss to follow-up, transferred-out patients and documented mortality. A multivariate Cox proportional hazard model showed that male sex, CD4 count <200 cells/µL and the type of HF were significantly associated with attrition.

conclusionsThe observed attrition differences according to gender suggest that separate interventions designed for women and men should be explored. Moreover, innovative strategies to increase HIV testing should be supported to avoid CD4 levels falling too low, a factor significantly associated with higher attrition in our study. Finally, specific studies to analyse the reasons for different levels of attrition among HFs are required.

Indexed as

antiretroviral treatmentattritionloss-to follow-upmortalityretention in care

Identifiers

PMID29082011
PMCPMC5656181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.