Evidence map›Paper›PMID 29081992›Full record

ArticleBMJ global health2017

Impact of a malaria intervention package in schools on

Siân E Clarke, Saba Rouhani, Seybou Diarra, Renion Saye, Modibo Bamadio, Rebecca Jones, Diahara Traore, Klenon Traore, Matthew Ch Jukes, Josselin Thuilliez and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ global health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  3. Systematic Review and Meta-Analysis of Seasonal Malaria Chemoprevention.The American journal of tropical medicine and hygiene · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Siân E ClarkeFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-3829-9584
Saba RouhaniFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Seybou DiarraSave the Children, Bamako, Mali.
Renion SayeMinistry of Health, Institut National de Recherche en Santé Publique, Bamako, Mali.
Modibo BamadioSave the Children, Bamako, Mali.
Rebecca JonesFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Diahara TraoreMinistry of Health, Programme National de Lutte contre le Paludisme, Bamako, Mali.
Klenon TraoreMinistry of Health, Programme National de Lutte contre le Paludisme, Bamako, Mali.
Matthew Ch JukesRTI International, Research Triangle Park, North Carolina, USA.
Josselin ThuilliezCNRS (Centre National de la Recherche Scientifique) - Centre d'Économie de la Sorbonne, Paris, France.
Simon BrookerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Natalie RoschnikSave the Children, Bamako, Mali.
Moussa SackoMinistry of Health, Institut National de Recherche en Santé Publique, Bamako, Mali.
London School of Hygiene & Tropical Medicine · GBMali-Folkecenter · MLCentre Pour le Développement des Vaccins-Mali · MLInstitut National de Recherche en Santé Publique · MLCentre National de la Recherche Scientifique · FRRTI International · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundSchool-aged children are rarely targeted by malaria control programmes, yet the prevalence of

methodsA cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs). Control schools received LLINs as part of the national universal net distribution programme. The impact of the interventions on malaria and anaemia was evaluated over 20 months using cross-sectional surveys in a random subset of 38 schools(all classes), with a range of cognitive measures (sustained attention, visual search, numeracy, vocabulary and writing) assessed in a longitudinal cohort of children aged 9-12 years in all 80 schools.

resultsDelivery of a single round of IPCs was associated with dramatic reductions in malaria parasitaemia (OR 0.005, 95% CI 0.002 to 0.011, p<0.001) and gametocyte carriage (OR 0.02, 95% CI 0.00 to 0.17, p<0.001) in intervention compared with control schools. This effect was sustained for 6 months until the beginning of the next transmission season. IPCs was also associated with a significant decrease in anaemia (OR 0.56, 95% CI 0.40 to 0.78, p=0.001), and increase in sustained attention (difference +0.23, 95% CI 0.10 to 0.36, p<0.001). There was no evidence of impact on other cognitive measures.

conclusionThe combination of malaria prevention education, LLINs and IPCs can reduce anaemia and improve sustained attention of school children in areas of highly seasonal transmission. These findings highlight the impact of asymptomatic malaria infection on cognitive performance in schoolchildren and the benefit of IPCs in reducing this burden. Additionally, malaria control in schools can help diminish the infectious reservoir that sustains

Indexed as

anaemiaasymptomaticcognitiongametocytesinsecticide-treated netsintermittent parasite clearanceintermittent preventive treatmentIPCIPTITNs. LLINsmalariaMalischoolchildrenschools

Identifiers

PMID29081992
PMCPMC5656118
OpenAlexW2727814220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.