Evidence map›Paper›PMID 29081966›Full record

ArticleJournal of tissue engineering

Design of biomimetic cellular scaffolds for co-culture system and their application.

Yun-Min Kook, Yoon Jeong, Kangwon Lee, Won-Gun Koh

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review on Advancement of AI in Cell Engineering and Molecular Biology.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Cells-Micropatterning Biomaterials for Immune Activation and Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Development ofAnnals of dermatology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yun-Min KookDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.
Yoon JeongProgram in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Kangwon LeeProgram in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Won-Gun KohDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix of most natural tissues comprises various types of cells, including fibroblasts, stem cells, and endothelial cells, which communicate with each other directly or indirectly to regulate matrix production and cell functionality. To engineer multicellular interactions in vitro, co-culture systems have achieved tremendous success achieving a more realistic microenvironment of in vivo metabolism than monoculture system in the past several decades. Recently, the fields of tissue engineering and regenerative medicine have primarily focused on three-dimensional co-culture systems using cellular scaffolds, because of their physical and biological relevance to the extracellular matrix of actual tissues. This review discusses several materials and methods to create co-culture systems, including hydrogels, electrospun fibers, microfluidic devices, and patterning for biomimetic co-culture system and their applications for specific tissue regeneration. Consequently, we believe that culture systems with appropriate physical and biochemical properties should be developed, and direct or indirect cell-cell interactions in the remodeled tissue must be considered to obtain an optimal tissue-specific microenvironment.

Indexed as

cellular scaffoldCo-cultureelectrospunhydrogeltissue engineering

Identifiers

PMID29081966
PMCPMC5564857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.