Evidence map›Paper›PMID 29081945›Full record

ArticleChemical science2017

Thiophene bridged aldehydes (TBAs) image ALDH activity in cells

Santanu Maity, Corinne M Sadlowski, Jung-Ming George Lin, Che-Hong Chen, Li-Hua Peng, Eun-Soo Lee, Giri K Vegesna, Charles Lee, Se-Hwa Kim, Daria Mochly-Rosen and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. A prodrug strategy for theRSC chemical biology · 2022
    Article
  4. Article
  5. Mapping Aldehyde Dehydrogenase 1A1 Activity using an [Chemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Santanu MaityDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.ORCID 0000-0001-8047-1547
Corinne M SadlowskiDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.ORCID 0000-0001-9688-1487
Jung-Ming George LinDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Che-Hong ChenDepartment of Chemical and Systems Biology , Stanford University , School of Medicine , Stanford , CA 94305-5174 , USA.
Li-Hua PengDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Eun-Soo LeeKorea Research Institute of Standards and Science , 267 Gajeong-ro, Yuseong-gu , Daejeon , Republic of Korea.
Giri K VegesnaDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Charles LeeDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Se-Hwa KimKorea Research Institute of Standards and Science , 267 Gajeong-ro, Yuseong-gu , Daejeon , Republic of Korea.
Daria Mochly-RosenDepartment of Chemical and Systems Biology , Stanford University , School of Medicine , Stanford , CA 94305-5174 , USA.
Sanjay KumarDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Niren MurthyDepartment of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email: nmurthy@berkeley.edu.
Huntington Hospital · USKorea Research Institute of Standards and Science · KRStanford Medicine · US

Funding

Consortium for drug-resistant Gram-negative pathogen detectionR01AI117064 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEE, LUKE P., MURTHY, NIREN · 2015 to 2019
$5.7M
Mechanisms of Ethanol-Induced Cardiac ProtectionR37AA011147 · NIAAA · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2009 to 2018
$5.3M
Rapid antimicrobial susceptibility determination of bacterial pathogensR01AI107116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DICKSON, ROBERT M, TZENG, YIH-LING · 2014 to 2017
$1.4M
Maltose Targeted AntibioticsR21AI119115 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI MURTHY, NIREN, RILEY, LEE W · 2015 to 2016
$414k
NIAAA NIH HHS R37 AA011147NIAID NIH HHS R01 AI107116NIAID NIH HHS R01 AI117064NIAID NIH HHS R21 AI119115
6 · The paper itself

Abstract

Aldehyde dehydrogenases (ALDHs) catalyze the oxidation of an aldehyde to a carboxylic acid and are implicated in the etiology of numerous diseases. However, despite their importance, imaging ALDH activity in cells is challenging due to a lack of fluorescent imaging probes. In this report, we present a new family of fluorescent probes composed of an oligothiophene flanked by an aldehyde and an electron donor, termed thiophene-bridged aldehydes (TBAs), which can image ALDH activity in cells. The TBAs image ALDH activity

Identifiers

PMID29081945
PMCPMC5635522
OpenAlexW2748696834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.