ArticleThe open ophthalmology journal2017
Conventional Versus Accelerated Collagen Cross-Linking for Keratoconus: A Comparison of Visual, Refractive, Topographic and Biomechanical Outcomes.
Article in The open ophthalmology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The effects of collagen cross-linking on corneal density: a comparison between accelerated and conventional methods.International ophthalmology · 2019Trial
- Evaluation of refractive, tomographic and biomechanical changes after customized accelerated corneal collagen cross-linking in keratoconus patients: a retrospective observational study.BMC ophthalmology · 2025Observational
- Long-term Effects and Prognostic Factors of Accelerated Cross-Linking with Retention Ring-assisted Riboflavin Application on Keratoconus Progression.Korean journal of ophthalmology : KJO · 2025Article
- The impact of interrupted corneal collagen crosslinking (CXL) treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Five-Year Long-Term Results of Standard Collagen Cross-Linking Therapy in Patients with KeratoconusTurkish journal of ophthalmology · 2020Article
- Accelerated corneal cross-linking with hypo-osmolar riboflavin in thin keratoconic corneas: 2-year follow-up.Arquivos brasileiros de oftalmologia · 2020Article
- Comparative Results of "Epi-Off" Conventional versus "Epi-Off" Accelerated Cross-Linking Procedure at 5-year Follow-Up.Journal of ophthalmology · 2020Article
- Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia.Systematic reviews · 2019Article
- Corneal densitometry after accelerated corneal collagen cross-linking in progressive keratoconus.International ophthalmology · 2019Article
- Corneal remodelling and topography following biological inlay implantation with combined crosslinking in a rabbit model.Scientific reports · 2019Article
- Effect of the retention ring-assisted continuous application of riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus.BMC ophthalmology · 2019Article
- Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus.Eye and vision (London, England) · 2019Article
- A Review of Corneal Collagen Cross-linking - Current Trends in Practice Applications.The open ophthalmology journal · 2018Review
- Standard and accelerated crosslinking protocols in keratoconus - differences and evolution at one year.Romanian journal of ophthalmologyArticle
- Accelerated versus Standard Corneal Cross-linking for Progressive Keratoconus in Syria.Journal of ophthalmic & vision researchArticle
- Accelerated Corneal Collagen Cross-Linking in Pediatric Keratoconus.Journal of current ophthalmologyArticle
- Combined photorefractive keratectomy and corneal collagen cross-linking for treatment of keratoconus: a 2-year follow-up study.Therapeutic advances in ophthalmologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated with either conventional or accelerated crosslinking at one year follow up.
methodsIt is a prospective, non-randomised interventional study of 76 patients who underwent conventional (CXL; 3mW/cm
resultsThe 2 groups were comparable in terms of uncorrected and best corrected visual acuity and spherical equivalent. Both groups showed no significant increase in K1, K2 and Kmean from baseline at 12 months. There was also no difference between the CXL and KXL group for postoperative corneal topography as well as central and minimal pachymetry up to 12 months. There was a significant increase in both corneal hysteresis (0.62mm Hg, P=0.04) and corneal resistance factor (0.91mm Hg, P=0.003) in the KXL group at 12 months but not in the CXL group. There was no significant endothelial cell loss throughout follow up in both the groups.
conclusionWe have established comparability of the 2 protocols in stabilizing the progression of keratoconus. Our findings also suggested an added biomechanical advantage of accelerated crosslinking at 1 year follow up.
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