ReviewInternational journal of endocrinology2017
Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.
Review in International journal of endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Subclinical Hypothyroidism on the Cardiovascular System
Impact Of Subclinical Hypothyroidism On Short-Term Outcomes In Patients With Acute Coronary Syndrome In Sohag University Hospitals
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Subclinical thyroid dysfunction and the risk of incident atrial fibrillation: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Pooled it
- The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies.Endocrinology and metabolism (Seoul, Korea) · 2020Pooled it
- Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis.BMJ open · 2019Pooled it
- Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases.Circulation. Genomic and precision medicine · 2019Pooled it
- Thyroid dysfunction and its associated factors: a cross-sectional study based on Rafsanjan cohort study in the southeast of Iran.BMJ open · 2026Article
- Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer.Discover oncology · 2025Article
- Thyroid Disorders and Their Impact on Metabolic Syndrome and Cardiovascular Risk: A Narrative Review.Cureus · 2025Review
- Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Establishing the TSH reference intervals for healthy adults aged over 70 years: the Australian ASPREE cohort study.Clinical chemistry and laboratory medicine · 2025Article
- Subclinical hypothyroidism and clinical outcomes after cardiac surgery: A systematic review and meta-analysis.JTCVS open · 2024Article
- Thyroid dysfunction and mortality in cardiovascular hospitalized patients.Cardiovascular endocrinology & metabolism · 2024Article
- Thyroid and cardiovascular diseases.Turkish journal of medical sciences · 2024Review
- Association between atherosclerosis and the development of multi-organ pathologies.SAGE open medicine · 2024Review
- Article
- Thyroid hormones and platelet activation in COVID-19 patients.Journal of endocrinological investigation · 2023Article
- Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naïve patients with major depressive disorder: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2023Article
- Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention.Ghana medical journal · 2023Observational
- Approach to adult patients with primary hypothyroidism in some special situations: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM).Archives of endocrinology and metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND
resultsPubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0.91-1.52), total mortality (RR = 1.02; 95% CI, 0.93-1.13), cardiovascular mortality (RR = 1.06; 95% CI, 0.77-1.45), heart failure (RR = 1.17; 95% CI, 0.87-1.57), and atrial fibrillation (RR = 1.05; 95% CI, 0.91-1.21), except CHD mortality (RR = 1.37; 95% CI, 1.03-1.84). Subgroup analysis indicated a higher estimation risk in CHD (RR = 1.54; 95% CI, 1.00-2.39), cardiovascular mortality (RR = 2.14; 95% CI, 1.43-3.22), and CHD mortality (RR = 1.54; 95% CI, 1.11-2.15) among participants < 65 years. Furthermore, subclinical hyperthyroidism was found to be associated with CHD (RR = 1.20; 95% CI, 1.02-1.42), total mortality (RR = 1.27; 95% CI, 1.07-1.51), and CHD mortality (RR = 1.45; 95% CI, 1.12-1.86).
conclusionsSubclinical hypothyroidism is likely associated with an increased risk of CHD mortality, and subclinical hyperthyroidism is likely associated with increased risk of CHD, CHD mortality, and total mortality.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.