Evidence map›Paper›PMID 29081696›Full record

ReviewCurrent genomics2017

Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice.

Marina V Nemtsova, Vladimir V Strelnikov, Alexander S Tanas, Igor I Bykov, Dmitry V Zaletaev, Viktoria V Rudenko, Alexander I Glukhov, Tatiana V Kchorobrich, Yi Li, Vadim V Tarasov and 2 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Review
  7. Long non-coding RNATranslational cancer research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Marina V NemtsovaInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
Vladimir V StrelnikovResearch Centre for Medical Genetics, Moskvorechie St. 1, 115472, Moscow, Russia.
Alexander S TanasResearch Centre for Medical Genetics, Moskvorechie St. 1, 115472, Moscow, Russia.
Igor I BykovDepartment No 1, Medical Faculty, Faculty Surgery, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
Dmitry V ZaletaevInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
Viktoria V RudenkoResearch Centre for Medical Genetics, Moskvorechie St. 1, 115472, Moscow, Russia.
Alexander I GlukhovDepartment of Biochemistry, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya, 8/2, Moscow, 119991, Russian Federation.
Tatiana V KchorobrichDepartment No 1, Medical Faculty, Faculty Surgery, Sechenov First Moscow State Medical University, Russian Ministry of Health, Trubetskaya St. 8/2, Moscow, 119991, Russian Federation.
Yi LiDepartment of Human Sciences, Texas A&M University-Kingsville, TX 78363, USA.
Vadim V TarasovInstitute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991Moscow, Russia.
George E BarretoDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, BogotáD.C., Colombia.
Gjumrakch Aliev"GALLY" International Biomedical Research Consulting LLC, San Antonio, TX78229, USA.
Research Centre for Medical Genetics · RUSechenov University · RUKurchatov Institute · RUMinistry of Health of the Russian Federation · RUPontificia Universidad Javeriana · COTexas A&M University – Kingsville · USUniversity of Atlanta · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe have investigated aberrant methylation of genes CDH1, RASSF1A, MLH1, N33, DAPK, expression of genes hTERT, MMP7, MMP9, BIRC5 (survivin), PTGS2, and activity of telomerase of 106 gastric tumor samples obtained intra-operatively and 53 gastric tumor samples from the same group of patients obtained endoscopically before surgery. Biopsy specimens obtained from 50 patients with chronic calculous cholecystitis were used as a control group. Together with tissue samples obtained from different sites remote to tumors, a total of 727 samples have been studied. The selected parameters comprise a system of molecular markers that can be used in both diagnostics of gastric cancer and in dynamic monitoring of patients after surgery. Special attention was paid to the use of molecular markers for the diagnostics of malignant process in the material obtained endoscopically since the efficacy of morphological diagnostics in biopsies is compromised by intratumoral heterogeneity, which may prevent reliable identification of tumor cells in the sampling. Our data indicated that certain molecular genetic events provided more sensitive yet specific markers of the tumor.

conclusionWe demonstrated that molecular profiles detected in preoperative biopsies were confirmed by the material obtained intra-operatively. The use of endoscopic material facilitates gastric tumors pre-operative diagnostics, improving early detection of gastric cancer and potential effective treatment strategies.

Indexed as

BiopsiesGastric cancerGenetic markersHeterogeneousMolecular profilesTreatment

Identifiers

PMID29081696
PMCPMC5635646
OpenAlexW2601838553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.