Evidence map›Paper›PMID 29081538›Full record

ArticleIsrael journal of chemistry2016

Mean First-Passage Times in Biology.

Nicholas F Polizzi, Michael J Therien, David N Beratan

Abstract read
In one paragraph

Article in Israel journal of chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Sources of non-Arrhenius electron transport in bacterial nanowires.Physical chemistry chemical physics : PCCP · 2026
    Article
  2. Article
  3. Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  4. Article
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  6. Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ.Protein science : a publication of the Protein Society · 2024
    Article
  7. Using single molecule imaging to explore intracellular heterogeneity.The international journal of biochemistry & cell biology · 2023
    Review
  8. Article
  9. Article
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  11. Article
  12. Review
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  16. Article
  17. Electrostatic influence on IL-1 transport through the GSDMD pore.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicholas F PolizziDepartment of Biochemistry, Duke University, Durham, NC 27710 (USA).
Michael J TherienDepartment of Chemistry, Duke University, Durham, NC 27708 (USA).
David N BeratanDepartment of Biochemistry, Duke University, Durham, NC 27710 (USA).

Funding

MAPPING OF ELECTRON TUNNELING PATHWAYS IN PROTEINSR01GM048043 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID BERATAN · 1993 to 2026
$6.0M
Charge-Transfer Dynamics Relevant to Protein-Mediated Energy TransductionR01GM071628 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI THERIEN, MICHAEL J · 2004 to 2014
$2.3M
NIGMS NIH HHS R01 GM048043NIGMS NIH HHS R01 GM071628
6 · The paper itself

Abstract

Many biochemical processes, such as charge hopping or protein folding, can be described by an average timescale to reach a final state, starting from an initial state. Here, we provide a pedagogical treatment of the mean first-passage time (MFPT) of a physical process, which depends on the number of intervening states between the initial state and the target state. Our aim in this tutorial review is to provide a clear development of the mean first-passage time formalism and to show some of its practical utility. The MFPT treatment can provide a useful link between microscopic rates and the average timescales often probed by experiment.

Indexed as

electron transferMarkov chainsmean first-passage timeprotein folding

Identifiers

PMID29081538
PMCPMC5656268

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.