Evidence map›Paper›PMID 29081506›Full record

ArticleInternational journal of obesity (2005)2018

Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery.

S Pellitero, I Piquer-Garcia, G Ferrer-Curriu, R Puig, E Martínez, P Moreno, J Tarascó, J Balibrea, C Lerin, M Puig-Domingo and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

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  19. New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

S PelliteroDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
I Piquer-GarciaDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
G Ferrer-CurriuDepartment of Biochemistry and Molecular Biomedicine. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
R PuigDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
E MartínezDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
P MorenoDepartment of Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
J TarascóDepartment of Surgery, Germans Trias i Pujol Research Institute, Barcelona, Spain.
J BalibreaMetabolic and Bariatric Surgery Unit, EAC-BS Center of Excellence, Vall d'Hebron University Hospital, Barcelona, Spain.
C LerinEndocrinology Department, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0003-0950-4363
M Puig-DomingoDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
F VillarroyaDepartment of Biochemistry and Molecular Biomedicine. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
A PlanavilaDepartment of Biochemistry and Molecular Biomedicine. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
D Sánchez-InfantesDepartment of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESSpanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESInstitut de Recerca Sant Joan de DéuVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bariatric surgery is currently the most effective therapy for type 2 diabetes. However, the mechanisms underlying its beneficial effects remain elusive. Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis. Metrnl and OSM levels were assessed at baseline, 6 and 12 months after laparoscopic sleeve gastrectomy (LSG) in 25 patients with obesity, as well as in 33 normal-weight controls. At baseline, patients with obesity showed lower Metrnl and higher OSM levels compared to controls. LSG increased Metrnl and decreased OSM levels, in correlation to improvements in glucose and lipid homeostasis. Our data indicate that LSG conversely modulated Metrnl and OSM levels, and suggest that a dual approach modulating these two molecules might provide a novel strategy for obesity and type 2 diabetes treatment.

Indexed as

AdipokinesAdultBariatric SurgeryCase-Control StudiesFemaleHumansMaleMiddle AgedObesityOncostatin MTreatment OutcomeAdipokinesMetrnl protein, humanOncostatin M

Identifiers

PMID29081506
OpenAlexW2767031986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.