ArticleInternational journal of obesity (2005)2018
The effects of muscle mass and muscle quality on cardio-metabolic risk in peripubertal girls: a longitudinal study from childhood to early adulthood.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Cardiometabolic risk and health behaviours in adolescents with normal-weight obesity: a systematic review.Public health nutrition · 2021Pooled it
- Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.Pediatric obesity · 2026Article
- Examining the mediating role of muscle quantity in adolescents: associations with adiposity, cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors.Scientific reports · 2024Article
- Are Women with Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?Biomedicines · 2023Article
- The inverse relationship between fatness and bone mineral content is mediated by the adolescent appendicular skeletal muscle mass index: The Cogni-Action Project.Frontiers in nutrition · 2022Article
- The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents.Frontiers in endocrinology · 2022Article
- Normal weight obesity and unaddressed cardiometabolic health risk-a narrative review.International journal of obesity (2005) · 2021Review
- Psoas muscle fluorine-18-labelled fluoro-2-deoxy-d-glucose uptake associated with the incidence of existing and incipient metabolic derangement.Journal of cachexia, sarcopenia and muscle · 2019Article
- Normal weight obesity and physical fitness in Chinese university students: an overlooked association.BMC public health · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased cardio-metabolic risk is well documented in children and adolescents with obesity and normal weight obesity (NWO). However, the associations of muscle mass and muscle quality with cardio-metabolic risk, independent of weight status from childhood to adulthood, has not been examined.
methodsA total of 236 girls were followed from pre-puberty to early adulthood. Fat mass (FM) and lean mass (LM) of the whole body were assessed by a dual-energy X-ray absorptiometry; muscle cross-sectional area (mCSA), muscle density (mDen; skeletal muscle fat content) of the lower leg by the peripheral quantitative computerized tomography; and blood glucose, insulin, triglycerides and high-density lipoprotein cholesterol by enzymatic photometric methods. Study participants were categorized based on body mass index (BMI) and percentage body fat (%BF) as overweight and/or obese (BMI⩾30 with %BF⩾30), normal weight obese (BMI 18.5-24.9 with %BF⩾30) and normal weight lean (BMI 18.5-24.9 with %BF <30).
resultsGirls with overweight and/or obesity from age of 11 to age 18 had greater LM and larger mCSA, but lower mDen and skeletal muscle mass index than the normal-weight girls (P<0.001 for all). Girls with NWO had similar mCSA and muscle mass but lower mDen and skeletal muscle index (SMI) than their normal-weight lean peers from childhood to early adulthood (P<0.001 all). In all girls, mDen and SMI were inversely associated with cardio-metabolic risk score (r
conclusionsSkeletal muscle size and muscle mass are not associated with cardio-metabolic risk factors during pubertal growth after adjusting for measures of adiposity. Ectopic fat accumulation in the skeletal muscle and increased adiposity, particularly in the abdominal area in childhood, are significant contributors to increased cardio-metabolic risk in adulthood, irrespective of body weight status.
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