Evidence map›Paper›PMID 29081387›Full record

ArticleParasitology international2018

Novel Toxoplasma gondii inhibitor chemotypes.

A G Sanford, T T Schulze, L P Potluri, R M Hemsley, J J Larson, A K Judge, S J Zach, X Wang, S A Charman, J L Vennerstrom and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Antischistosomal Ozonide Glycine Ethyl Esters.ACS medicinal chemistry letters · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Analogs of Marinopyrrole A Show Enhancement to ObservedAntimicrobial agents and chemotherapy · 2022
    Article
  8. Diaryl Ureas as an Antiprotozoal Chemotype.ACS infectious diseases · 2021
    Article
  9. Antimicrobial agents and chemotherapy · 2021
    Article
  10. Neurological and Neurobehavioral Disorders Associated withJournal of parasitology research · 2021
    Review
  11. Article
  12. A new chemotype with promise against Trypanosoma cruzi.Bioorganic & medicinal chemistry letters · 2020
    Article
  13. Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii.International journal for parasitology. Drugs and drug resistance · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A G SanfordDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
T T SchulzeDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
L P PotluriDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
R M HemsleyDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
J J LarsonDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
A K JudgeDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
S J ZachDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
X WangCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
S A CharmanCentre for Drug Candidate Optimization, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
J L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
P H DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA. Electronic address: pdavis@unomaha.edu.

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
Optimization of Antischistosomal ChemotypesR01AI116723 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2015 to 2024
$6.2M
NIAID NIH HHS R01 AI116723NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit T. gondii in vitro with IC

Indexed as

Drug DiscoveryAnimalsAntiprotozoal AgentsCell LineHigh-Throughput Screening AssaysMicePyrimethamineToxoplasmaToxoplasmosisAntiprotozoal AgentsPyrimethamineAnti-parasiticsDrug discoveryLead compoundsPlasmodium falciparumToxoplasma gondii

Identifiers

PMID29081387
PMCPMC5809185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.