Evidence map›Paper›PMID 29081304›Full record

ArticleEpidemiology and infection2017

Genotype and genetic variation of HCV infections with low-risk factors in Putian coastal regions, China.

X M Li, R X Qiu, C H Song, Q H Huang, X D Wang, Z T Hu, X Z He, X Y Ye, X G Huang, F F Zheng and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

X M LiLaboratory of Research Center, Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
R X QiuDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
C H SongDepartment of Gastroenterology,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
Q H HuangDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
X D WangDepartment of Infectious Diseases,First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China.
Z T HuDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
X Z HeDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
X Y YeDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
X G HuangDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
F F ZhengDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
G X LinDepartment of Infectious Diseases,Affiliated Hospital (Group) of Putian University,Putian 351100,Fujian,China.
Putian University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) infection is one of the leading causes of death and morbidity associated with liver disease. Risk factors identified for the transmission of HCV include contaminated blood products, intravenous drug use, body piercing, an infected mother at birth, sexual activity, and dental therapy, among others. However, the exact diversity of the HCV genotype and genetic variation among patients with low-risk factors is still unknown. In this study, we briefly described and analysed the genotype distribution and genetic variation of HCV infections with low-risk factors using molecular biology techniques. The results suggested that genotype 1b was predominant, followed by genotypes 2a and 1a. Genetic variations in the 5' UTR sequences of HCV were identified, including point mutations, deletions, and insertions. The frequency of genetic variations in 1b was higher than in 2a. This study provides considerable value for the prevention and treatment of liver disease caused by HCV among patients with low-risk factors and for the development of HCV diagnostic reagents and vaccines.

Indexed as

AdultAgedAged, 80 and overChinaFemaleGenetic VariationGenotypeHepacivirusHepatitis CHumansMaleMiddle AgedPhylogenyRisk FactorsRNA, ViralSequence Analysis, RNARNA, Viral5′ UTRgenetic variationgenotypeHepatitis C virusphylogenetic treerisk factor

Identifiers

PMID29081304
PMCPMC9148788
OpenAlexW2766690171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.