Evidence map›Paper›PMID 29081250›Full record

Trial reportNeurorehabilitation and neural repair

Effects of Training Intensity on Locomotor Performance in Individuals With Chronic Spinal Cord Injury: A Randomized Crossover Study.

Gabrielle Brazg, Meghan Fahey, Carey L Holleran, Mark Connolly, Jane Woodward, Patrick W Hennessy, Brian D Schmit, T George Hornby

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04973852 (High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04973852 nacompletednot on this map

High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2021 to 2023Enrolled11ConditionsSpinal Cord InjuriesArmsEkso
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Gabrielle Brazg1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Meghan Fahey1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Carey L Holleran2 Washington University, St Louis, MO, USA.
Mark Connolly1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Jane Woodward1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Patrick W Hennessy1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Brian D Schmit3 Northwestern University, Chicago, IL, USA.
T George Hornby1 Rehabilitation Institute of Chicago, Chicago, IL, USA.
Shirley Ryan AbilityLab · USIndiana University – Purdue University Indianapolis · USNorthwestern University · USWashington University in St. Louis · US

Funding

Sympathetic-somatomotor coupling in human SCIR01NS079751 · NINDS · MARQUETTE UNIVERSITY · PI HORNBY, THOMAS GEORGE, SCHMIT, BRIAN D · 2013 to 2017
$1.6M
NINDS NIH HHS R01 NS079751
6 · The paper itself

Abstract

backgroundMany physical interventions can improve locomotor function in individuals with motor incomplete spinal cord injury (iSCI), although the training parameters that maximize recovery are not clear. Previous studies in individuals with other neurologic injuries suggest the intensity of locomotor training (LT) may positively influence walking outcomes. However, the effects of intensity during training of individuals with iSCI have not been tested.

objectiveThe purpose of this pilot, blinded-assessor randomized trial was to evaluate the effects of LT intensity on walking outcomes in individuals with iSCI.

methodsUsing a crossover design, ambulatory participants with iSCI >1 year duration performed either high- or low-intensity LT for ≤20 sessions over 4 to 6 weeks. Four weeks following completion, the training interventions were alternated. Targeted intensities focused on achieving specific ranges of heart rate (HR) or ratings of perceived exertion (RPE), with intensity manipulated by increasing speeds or applying loads.

resultsSignificantly greater increases in peak treadmill speeds (0.18 vs 0.02 m/s) and secondary measures of metabolic function and overground speed were observed following high- versus low-intensity training, with no effects of intervention order. Moderate to high correlations were observed between differences in walking speed or distances and differences in HRs or RPEs during high- versus low-intensity training.

conclusionThis pilot study provides the first evidence that the intensity of stepping practice may be an important determinant of LT outcomes in individuals with iSCI. Whether such training is feasible in larger patient populations and contributes to improved locomotor outcomes deserves further consideration.

Indexed as

Physical Therapy ModalitiesAdolescentAdultAgedCross-Over StudiesExercise TestFemaleGait Disorders, NeurologicHeart RateHumansLocomotionMaleMiddle AgedRecovery of FunctionSpinal Cord InjuriesTreatment Outcomeexercise intensitylocomotor trainingspinal cord injury

Identifiers

PMID29081250
PMCPMC5729047
OpenAlexW2765855220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.