ReviewJournal of assisted reproduction and genetics2017
Is mitochondrial DNA quantitation in blastocyst trophectoderm cells predictive of developmental competence and outcome in clinical IVF?
Review in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles.Journal of assisted reproduction and genetics · 2023Article
- Mitochondrial DNA quantification correlates with the developmental potential of human euploid blastocysts but not with that of mosaic blastocysts.BMC pregnancy and childbirth · 2023Article
- Article
- Reduced mitochondrial DNA content correlate with poor clinical outcomes in cryotransfers with day 6 single euploid embryos.Frontiers in endocrinology · 2022Article
- Pronuclear score improves prediction of embryo implantation success in ICSI cycles.BMC pregnancy and childbirth · 2021Observational
- Equine maternal aging affects oocyte lipid content, metabolic function and developmental potential.Reproduction (Cambridge, England) · 2021Article
- Suboptimal trophectoderm mitochondrial DNA level is associated with delayed blastocyst development.Journal of assisted reproduction and genetics · 2021Article
- Adjusted mitochondrial DNA quantification in human embryos may not be applicable as a biomarker of implantation potential.Journal of assisted reproduction and genetics · 2019Observational
- mtDNA dynamics between cleavage-stage embryos and blastocysts.Journal of assisted reproduction and genetics · 2019Article
- Cleavage stage mitochondrial DNA is correlated with preimplantation human embryo development and ploidy status.Journal of assisted reproduction and genetics · 2019Article
- Comprehensive mitochondrial DNA analysis and IVF outcome.Human reproduction open · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behind every successful IVF embryo transfer, there is a great game of chance. Methods seeking to tilt the balance and increase the likelihood of implantation have been proposed and implemented with varying results, including embryo morphology, FISH-PGS, comprehensive chromosomal screening (CCS), morphokinetics, endometrial receptivity testing. It has been suggested that mitochondrial DNA (mtDNA) copy number could serve as a biomarker for embryo viability, but this concept was recently challenged. The world of IVF is left with unanswered questions: Why are there discrepancies in the reports? Should mtDNA copy number be considered to rank embryos for transfer? And in a broader sense, how well must a technique be validated before its implementation in the IVF clinic? Here, we explore these questions attempting to piece together the published data and suggest future directions to help unravel the subject matter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.