Evidence map›Paper›PMID 29080864›Full record

ArticleJournal of the American Heart Association2017

Endothelial Progenitor Cell Biology and Vascular Recovery Following Transradial Cardiac Catheterization.

Andrew Mitchell, Takeshi Fujisawa, Nicholas L Mills, Mairi Brittan, David E Newby, Nicholas L M Cruden

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02147119 (Radial Artery Function Following Trans-radial Cardiac Catheterisation), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02147119 completednot on this map

Radial Artery Function Following Trans-radial Cardiac Catheterisation

TypeobservationalSponsorUniversity of EdinburghRan2014 to 2015Enrolled5ConditionsAtherosclerosisArmsCoronary angiography
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrew MitchellBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom andrewjmitchell@doctors.org.uk.
Takeshi FujisawaBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
Nicholas L MillsBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
Mairi BrittanBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
David E NewbyBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
Nicholas L M CrudenBHF/University Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
University of Edinburgh · GBMRC Centre for Regenerative Medicine · GBNHS Lothian · GB

Funding

British Heart Foundation FS/10/024/28266British Heart Foundation FS/16/14/32023British Heart Foundation FS/16/4/31831British Heart Foundation PG/13/32/30205
6 · The paper itself

Abstract

backgroundTransradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. METHODS AND

resultsIn 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths. Flow- and nitrate-mediated dilatation of the radial artery was assessed in both arms at baseline, at 24 hours, and at 1, 4, and 12 weeks. Circulating endothelial progenitor cell populations were quantified using flow cytometry. Late endothelial outgrowth colonies were isolated and examined in vitro. Optical coherence tomography identified macroscopic injury in 12 of 50 patients (24%), but endothelial cells (1.9±1.2×10

conclusionsTransradial cardiac catheterization causes endothelial denudation, vascular injury, and vasomotor dysfunction that recover over 12 weeks. Recovery of vascular function does not appear to be dependent on the mobilization or function of endothelial progenitor cells. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02147119.

Indexed as

Cell MovementCell ProliferationAC133 AntigenAgedAntigens, CD34Cardiac CatheterizationCatheterization, PeripheralCells, CulturedCell SeparationEndothelial Progenitor CellsFemaleFlow CytometryHumansMaleMiddle AgedPhenotypeAC133 AntigenAntigens, CD34PROM1 protein, humancardiac catheterizationendothelial cellendothelial functionradial artery cathetervascular imaging

Identifiers

PMID29080864
PMCPMC5721759
OpenAlexW2765166670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.