ArticleExperimental gerontology2018
Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes.
Article in Experimental gerontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Intoxication, inflammaging, and injury: my journey through leukocyte biology.Journal of leukocyte biology · 2026Article
- Deep learning guided propofol ketamine dosing and inflammation trajectories in elderly burns.Frontiers in computational neuroscience · 2026Article
- Advanced Age Worsens Respiratory Function and Pulmonary Inflammation After Burn Injury and This Correlates With Changes in the Fecal Microbiome in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.The Journal of surgical research · 2023Article
- Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function.Alcohol (Fayetteville, N.Y.) · 2023Article
- Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice.Experimental gerontology · 2022Article
- Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Inhalation Injury Is Associated With Endotheliopathy and Abnormal Fibrinolytic Phenotypes in Burn Patients: A Cohort Study.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Advanced age exacerbates intestinal epithelial permeability after burn injury in mice.Experimental gerontology · 2022Article
- Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut.Advances in geriatric medicine and research · 2022Article
- How Inflammation Blunts Innate Immunity in Aging.Interdisciplinary topics in gerontology and geriatrics · 2020Review
- Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists.Aging clinical and experimental research · 2019Article
- Inhalation Injury: Unmet Clinical Needs and Future Research.Journal of burn care & research : official publication of the American Burn Association · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR)=7.37 per 10years, p=0.004). In plasma collected within 15h after burn injury, significant increases in the concentrations of interleukin 1 receptor antagonist (IL-1RA), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), granulocyte colony-stimulating factor (G-CSF), interferon-gamma-induced protein 10 (IP-10) and monocyte chemoattractant protein 1 (MCP-1) (p<0.05 for all) were observed in the ≥65 group. In the BAL fluid, MCP-1 was increased three-fold in the ≥65 group. This study suggests that changes in certain immune mediators were present in the older cohort, in association with in-hospital mortality.
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Registered trials
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