ArticleNeuroImage2018
Hippocampal morphology mediates biased memories of chronic pain.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- The functional role of opioidergic system within the ventral tegmental area and the dentate gyrus of hippocampus in modulation of the persistent inflammatory pain in the rats.IBRO neuroscience reports · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review.Brain and behavior · 2025Review
- Physiological Sensor Modality Sensitivity Test for Pain Intensity Classification in Quantitative Sensory Testing.Sensors (Basel, Switzerland) · 2025Article
- Article
- Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia.Brain imaging and behavior · 2025Article
- Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Assessing cognitive biases induced by acute formalin or hotplate treatment: an animal study using affective bias test.Frontiers in behavioral neuroscience · 2024Article
- Pain Management in the Most Vulnerable Intellectual Disability: A Review.Pain and therapy · 2023Review
- Altered brain activities in mesocorticolimbic pathway in primary dysmenorrhea patients of long-term menstrual pain.Frontiers in neuroscience · 2023Article
- Disentangling the neurological basis of chronic ocular pain using clinical, self-report, and brain imaging data: use of K-means clustering to explore patient phenotypes.Frontiers in neurology · 2023Article
- Comparing recalled versus experienced symptoms of breathlessness ratings: An ecological assessment study using mobile phone technology.Respirology (Carlton, Vic.) · 2022Article
- Functional Connectivity Features of Resting-State Functional Magnetic Resonance Imaging May Distinguish Migraine From Tension-Type Headache.Frontiers in neuroscience · 2022Article
- Assessing Pain Research: A Narrative Review of Emerging Pain Methods, Their Technosocial Implications, and Opportunities for Multidisciplinary Approaches.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Painful reminders: Involvement of the autobiographical memory system in pediatric postsurgical pain and the transition to chronicity.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- The Use of Neuroimaging for Predicting Sumatriptan Treatment Response in Patients With Migraine.Frontiers in neurology · 2022Article
- Brain mechanisms of chronic pain: critical role of translational approach.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.Pain · 2021Article
- Brain Imaging Biomarkers for Chronic Pain.Frontiers in neurology · 2021Review
- Pre-operative Limbic System Functional Connectivity Distinguishes Responders From Non-responders to Surgical Treatment for Trigeminal Neuralgia.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Experiences and memories are often mismatched. While multiple studies have investigated psychological underpinnings of recall error with respect to emotional events, the neurobiological mechanisms underlying the divergence between experiences and memories remain relatively unexplored in the domain of chronic pain. Here we examined the discrepancy between experienced chronic low back pain (CBP) intensity (twice daily ratings) and remembered pain intensity (n = 48 subjects) relative to psychometric properties, hippocampus morphology, memory capabilities, and personality traits related to reward. 77% of CBP patients exaggerated remembered pain, which depended on their strongest experienced pain and their most recent mood rating. This bias persisted over nearly 1 year and was related to reward memory bias and loss aversion. Shape displacement of a specific region in the left posterior hippocampus mediated personality effects on pain memory bias, predicted pain memory bias in a validation CBP group (n = 21), and accounted for 55% of the variance of pain memory bias. In two independent groups (n = 20/group), morphology of this region was stable over time and unperturbed by the development of chronic pain. These results imply that a localized hippocampal circuit, and personality traits associated with reward processing, largely determine exaggeration of daily pain experiences in chronic pain patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.