ReviewEndocrinology and metabolism clinics of North America2017
Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?
Review in Endocrinology and metabolism clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Vitamin D Metabolic Pathway Components in Orthopedic Patientes-Systematic Review.International journal of molecular sciences · 2022Pooled it
- Vitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Trial
- Total, Bioavailable, and Free 25(OH)D Relationship with Indices of Bone Health in Elderly: A Randomized Controlled Trial.The Journal of clinical endocrinology and metabolism · 2021Trial
- Evaluation of correlations between serum and urinary vitamin D metabolites using LC-MS/MS.Bioscience reports · 2026Article
- Does Vitamin D-Binding Protein Predict Response to Vitamin D Supplementation in Term and Preterm Newborns? A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Bone mineral density using dual-energy X-ray absorptiometry in children with nephrotic syndrome: a cross-sectional study.International urology and nephrology · 2026Article
- 25(OH)D3 and F-25(OH)D as indicators of chronic kidney disease progression in patients with rheumatoid arthritis.Scientific reports · 2025Article
- Review
- Role of Calcitriol and Vitamin D Receptor (International journal of molecular sciences · 2024Review
- Circulating total 25(OH)D and calculated free 25(OH)D in professional academy footballers at a northerly latitude in the UK.Biology of sport · 2024Article
- Review
- Seasonal variation of total and bioavailable 25-hydroxyvitamin D [25(OH)D] in the healthy adult Slovenian population.Acta biochimica Polonica · 2024Article
- Effects of vitamin D and L-cysteine cosupplementation on circulating bioavailable and total 25-hydroxy-vitamin D, the free/total testosterone ratio and inflammatory biomarkers in healthy vitamin D-deficient African Americans: a placebo-controlled double-blind clinical trial.BMJ nutrition, prevention & health · 2024Article
- "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.Hormones (Athens, Greece) · 2023Review
- Development and Validation of Novel Free Vitamin D Equations: The Health Aging and Body Composition Study.JBMR plus · 2023Article
- Metabolism and pharmacokinetics of vitamin D in patients with cystic fibrosis.The Journal of steroid biochemistry and molecular biology · 2023Article
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer.Frontiers in nutrition · 2023Article
- Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.The American journal of clinical nutrition · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert their biologic effects. For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.