Evidence map›Paper›PMID 29080504›Full record

ArticleColloids and surfaces. B, Biointerfaces2018

Isolation of Breast cancer CTCs with multitargeted buoyant immunomicrobubbles.

Guankui Wang, Halli Benasutti, Jessica F Jones, Guixin Shi, Michael Benchimol, Sandeep Pingle, Santosh Kesari, Yasan Yeh, Li-En Hsieh, Yu-Tsueng Liu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Laboratory-Scale Production of Sterile Targeted Microbubbles.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Guankui WangDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Blvd., Aurora, CO 80045, USA.
Halli BenasuttiDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Blvd., Aurora, CO 80045, USA.
Jessica F JonesDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Blvd., Aurora, CO 80045, USA.
Guixin ShiDiagnologix, LLC, 5820 Oberlin Drive, Suite 104, San Diego, CA 92121, USA.
Michael BenchimolDiagnologix, LLC, 5820 Oberlin Drive, Suite 104, San Diego, CA 92121, USA.
Sandeep PingleDepartment of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.
Santosh KesariDepartment of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.
Yasan YehMoores UCSD Cancer Center, University of California San Diego,3855 Health Sciences Drive, La Jolla, CA 92093, USA.
Li-En HsiehMoores UCSD Cancer Center, University of California San Diego,3855 Health Sciences Drive, La Jolla, CA 92093, USA.
Yu-Tsueng LiuMoores UCSD Cancer Center, University of California San Diego,3855 Health Sciences Drive, La Jolla, CA 92093, USA. Electronic address: ytliu@ucsd.edu.
Anthony EliasUniversity of Colorado Cancer Center, Breast & Sarcoma Programs, Department of Medicine, University of Colorado, 1665 Aurora Court, Aurora, CO 80045, USA.
Dmitri SimbergDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Blvd., Aurora, CO 80045, USA. Electronic address: dmitri.simberg@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USUniversity of California, San Diego · USDiagnologix (United States) · USSaint John's Health Center · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Painted erythrocyte carriers for therapy of acute myeloid leukemiaR01CA194058 · NCI · UNIVERSITY OF COLORADO DENVER · PI SIMBERG, DMITRI · 2016 to 2020
$1.8M
Buoyancy based bioseparationsR44CA176892 · NCI · DIAGNOLOGIX, LLC · PI SHI, GUIXIN · 2015 to 2016
$1.0M
High quality CTC isolation using microbubbles for downstream molecular analysisR33CA174554 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIU, YU-TSUENG · 2013 to 2015
$956k
Buoyancy based bioseparationsR43CA176892 · NCI · DIAGNOLOGIX, LLC · PI BENCHIMOL, MICHAEL · 2013 to 2014
$169k
NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA194058NCI NIH HHS R33 CA174554NCI NIH HHS R43 CA176892NCI NIH HHS R44 CA176892
6 · The paper itself

Abstract

Circulating tumor cells (CTCs) are extremely rare cells found in blood of metastatic cancer patients. There is a need for inexpensive technologies for fast enrichment of CTCs from large blood volumes. Previous data showed that antibody-conjugated lipid shell immuno-microbubbles (MBs) bind and isolate cells from biological fluids by flotation. Here, blood-stable MBs targeted to several surface markers for isolation of breast tumor cells were developed. MBs coated with anti-human EpCAM antibodies showed efficient binding of EpCAM

Indexed as

MicrobubblesBiomarkers, TumorBreast NeoplasmsCell Line, TumorCell SeparationEpithelial Cell Adhesion MoleculeFemaleHumansKeratinsMCF-7 CellsNeoplastic Cells, CirculatingBiomarkers, TumorEpithelial Cell Adhesion MoleculeKeratinsAntibodyBreast cancerCTCEGFREpCAMMicrobubbles

Identifiers

PMID29080504
PMCPMC5726926
OpenAlexW2766877270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.