ArticleDevelopmental cognitive neuroscience2017
An electrophysiological investigation of reinforcement effects in attention deficit/hyperactivity disorder: Dissociating cue sensitivity from down-stream effects on target engagement and performance.
Article in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Dissociated in Anticipation, Common in Feedback: Neuroelectrophysiological Mechanisms of Social-Motivational Processing in Bivalent Evaluation Fears.Psychophysiology · 2026Article
- Electrophysiological indices of reward anticipation as ADHD risk and prognostic biomarkers.European child & adolescent psychiatry · 2025Article
- Reliability of reward ERPs in middle-late adolescents using a custom and a standardized preprocessing pipeline.Psychophysiology · 2022Article
- The limits of motivational influence in ADHD: no evidence for an altered reaction to negative reinforcement.Social cognitive and affective neuroscience · 2022Article
- I, robot: depression plays different roles in human-human and human-robot interactions.Translational psychiatry · 2021Article
- Review
- Task-related motivation and academic achievement in children and adolescents with ADHD.European child & adolescent psychiatry · 2021Article
- Altered Neural Processing of Reward and Punishment in Women With Methamphetamine Use Disorder.Frontiers in psychiatry · 2021Article
- Electrophysiological correlates of spontaneous mind wandering in attention-deficit/hyperactivity disorder.Behavioural brain research · 2020Article
- In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD.Medical devices (Auckland, N.Z.) · 2020Review
- The reinforcing value of delay escape in attention deficit/hyperactivity disorder: An electrophysiological study.NeuroImage. Clinical · 2019Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeural hypo-sensitivity to cues predicting positive reinforcement has been observed in ADHD using the Monetary Incentive Delay (MID) task. Here we report the first study using an electrophysiological analogue of this task to distinguish between (i) cue related anticipation of reinforcement and downstream effects on (ii) target engagement and (iii) performance in a clinical sample of adolescents with ADHD and controls.
methodsThirty-one controls and 32 adolescents with ADHD aged 10-16 years performed the electrophysiological (e)-MID task - in which preparatory cues signal whether a response to an upcoming target will be reinforced or not - under three conditions; positive reinforcement, negative reinforcement (response cost) and no consequence (neutral). We extracted values for both cue-related potentials known to be, both, associated with response preparation and modulated by reinforcement (Cue P3 and Cue CNV) and target-related potentials (target P3) and compared these between ADHD and controls.
resultsADHD and controls did not differ on cue-related components on neutral trials. Against expectation, adolescents with ADHD displayed Cue P3 and Cue CNV reinforcement-related enhancement (versus neutral trials) compared to controls. ADHD individuals displayed smaller target P3 amplitudes and slower and more variable performance - but effects were not modulated by reinforcement contingencies. When age, IQ and conduct problems were controlled effects were marginally significant but the pattern of results did not change. DISCUSSION: ADHD was associated with hypersensitivity to positive (and marginally negative) reinforcement reflected on components often thought to be associated with response preparation - however these did not translate into improved attention to targets. In the case of ADHD, upregulated CNV may be a specific marker of hyper-arousal rather than an enhancement of anticipatory attention to upcoming targets. Future studies should examine the effects of age, IQ and conduct problems on reinforcement sensitivity in ADHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.