Evidence map›Paper›PMID 29080265›Full record

Trial reportStem cells translational medicine2017

Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial.

Jessica M Sun, Allen W Song, Laura E Case, Mohamad A Mikati, Kathryn E Gustafson, Ryan Simmons, Ricki Goldstein, Jodi Petry, Colleen McLaughlin, Barbara Waters-Pick and 6 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 75 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01147653 phase2completednot on this map

Is Autologous Umbilical Cord Blood Reinfusion Beneficial in Children With Cerebral Palsy: A Randomized, Blinded, Placebo-Controlled, Crossover Study

TypeinterventionalSponsorJoanne Kurtzberg, MDRan2010 to 2016Enrolled63ConditionsCerebral Palsy, CP, Spastic Cerebral PalsyArmsAutologous UCB Reinfusion, Placebo
NCT03791372 phase1unknown statusnot on this map

Clinical Effect and Safety of Autologous Umbilical Cord Blood Transfusion in the Treatment of Cerebral Palsy

TypeinterventionalSponsorGuangdong Women and Children HospitalRan2017 to 2021Enrolled25ConditionsSafety Issues, Effect of DrugsArms0.9% Sodium Chloride, Autologous Umbilical Cord Blood
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  4. Hybrid umbilical cord blood banking: literature review.Archives of gynecology and obstetrics · 2024
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jessica M SunThe Robertson Clinical and Translational Cell Therapy Program, Duke University, Durham, North California, USA.ORCID 0000-0001-8085-1013
Allen W SongThe Brain Imaging and Analysis Center, Duke University, Durham, North California, USA.
Laura E CaseDepartment of Physical and Occupational Therapy, Duke University, Durham, North California, USA.
Mohamad A MikatiDivision of Pediatric Neurology, Duke University, Durham, North California, USA.
Kathryn E GustafsonDepartment of Psychiatry, Duke University, Durham, North California, USA.
Ryan SimmonsThe Robertson Clinical and Translational Cell Therapy Program, Duke University, Durham, North California, USA.
Ricki GoldsteinDivision of Neonatology, Duke University, Durham, North California, USA.
Jodi PetryDepartment of Physical and Occupational Therapy, Duke University, Durham, North California, USA.
Colleen McLaughlinThe Robertson Clinical and Translational Cell Therapy Program, Duke University, Durham, North California, USA.
Barbara Waters-PickStem Cell Transplant Laboratory, Duke University, Durham, North California, USA.
Lyon W ChenThe Brain Imaging and Analysis Center, Duke University, Durham, North California, USA.
Stephen WeaseThe Emmes Corporation, Rockville, Maryland, USA.
Beth BlackwellThe Emmes Corporation, Rockville, Maryland, USA.
Gordon WorleyDivision of Pediatric Neurology, Duke University, Durham, North California, USA.
Jesse TroyThe Robertson Clinical and Translational Cell Therapy Program, Duke University, Durham, North California, USA.
Joanne KurtzbergThe Robertson Clinical and Translational Cell Therapy Program, Duke University, Durham, North California, USA.

Funding

High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell TherapyR01NS075017 · NINDS · DUKE UNIVERSITY · PI SONG, ALLEN W · 2012 to 2021
$3.4M
NINDS NIH HHS R01 NS075017
6 · The paper itself

Abstract

Cerebral palsy (CP) is a condition affecting young children that causes lifelong disabilities. Umbilical cord blood cells improve motor function in experimental systems via paracrine signaling. After demonstrating safety, we conducted a phase II trial of autologous cord blood (ACB) infusion in children with CP to test whether ACB could improve function (ClinicalTrials.gov, NCT01147653; IND 14360). In this double-blind, placebo-controlled, crossover study of a single intravenous infusion of 1-5 × 10

Indexed as

ConnectomeMotor SkillsBlood TransfusionBrainCerebral PalsyChildChild, PreschoolFemaleFetal BloodHumansInfantMaleMovementAutologous stem cell transplantationCellular therapyClinical TrialsCord bloodHuman cord bloodNervous systemUmbilical cord blood

Identifiers

PMID29080265
PMCPMC5702515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.