ReviewChinese journal of integrative medicine2017
Nitric oxide signaling molecules in acupoints: Toward mechanisms of acupuncture.
Review in Chinese journal of integrative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Insomnia Pathogenesis and Multidimensional Mechanisms of Acupuncture: A Narrative Review.International journal of general medicine · 2026Review
- Nitric oxide: a gas transmitter in healthy and diseased skin.Medical gas research · 2025Review
- Effectiveness of acupuncture for equine laminitis: Systematic review and meta-analysis.Veterinary world · 2025Review
- Stimuli-evoked NOergic molecules and neuropeptides at acupuncture points and the gracile nucleus contribute to signal transduction of propagated sensation along the meridian through the dorsal medulla-thalamic pathways.Journal of integrative medicine · 2024Review
- Acupoint transplantation versus non-acupoint transplantation using autologous peripheral blood mononuclear cells in treating peripheral arterial disease.Blood science (Baltimore, Md.) · 2024Article
- Stimuli-induced NOergic Molecules and Neuropeptides Mediated Axon Reflexes Contribute to Tracers along Meridian Pathways.Current topics in medicinal chemistry · 2024Review
- Laser acupuncture for claudication symptoms in peripheral artery disease - Does it work? A randomized trial.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2022Article
- The Role of Acupuncture for Long COVID: Mechanisms and Models.Medical acupuncture · 2022Article
- Changes of local microenvironment and systemic immunity after acupuncture stimulation during inflammation: A literature review of animal studies.Frontiers in neurology · 2022Review
- Comparison of physical electrical conductivity and acupuncture de-qi sensation between stainless steel needling and supercritical fluid-treated needling.Biomedical journal · 2021Article
- Effect of Shexiang Baoxin Pill () in Alleviating Early Hypertensive Renal Injury in Rats.Chinese journal of integrative medicine · 2021Article
- In Vivo Visualization of the Pericardium Meridian with Fluorescent Dyes.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Purines Change at Acupoints along the Pericardium Meridian in Healthy and Myocardial Ischemic Rats.Chinese journal of integrative medicine · 2019Article
- Underestimated Cervical Extradural Hematoma Secondary to the Small Needle-Scalpel for the Treatment of Cervical Spondylosis: A Rare but Avoidable Complication.Frontiers in neurology · 2019Article
- Resolution of Refractory Headache Symptoms Following Cervical Spinal Manipulation and Electrical Dry Needling in an Adolescent Female: A Case Report.Sage open pediatricsArticle
- The scientific basis of acupuncture for veterinary pain management: A review based on relevant literature from the last two decades.Open veterinary journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent clinical trial studies have demonstrated that the effects of acupuncture on pain improvement are small and no difference between acupoints and non-points. Whether acupuncture needles must be inserted in specific points depends on whether acupoint specificity exists that is still not resolved, and is now urgent. Previous anatomical studies have demonstrated that acupoints exist higher number of nerve fibers/trunks, blood vessels, hair follicles, and sweat glands as well as density of the gap junction. Recent evidence shows that nitric oxide (NO) level is elevated in the acupoints/ meridians and is associated with an enhanced expression of NO synthase endowed with transient receptor potential vanilloid type-1. There is growing evidence from international groups showing that acupuncture induces NO-mediated vasodilatation, which increases local blood flow and allows for a flush of algesic or sensitizing substances, leading to pain relief. Previous studies, using a novel biocapture system, have demonstrated that NOx
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.