Evidence map›Paper›PMID 29080114›Full record

ReviewMycopathologia2017

A Twenty-First-Century Perspective of Disseminated Histoplasmosis in India: Literature Review and Retrospective Analysis of Published and Unpublished Cases at a Tertiary Care Hospital in North India.

Ayush Gupta, Arnab Ghosh, Gagandeep Singh, Immaculata Xess

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Histoplasmosis in Children; HIV/AIDS Not a Major Driver.Journal of fungi (Basel, Switzerland) · 2021
    Review
  13. Paediatric Histoplasmosis 2000-2019: A Review of 83 Cases.Journal of fungi (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. ADRENAL HISTOPLASMOSIS: AN EASTERN INDIAN PERSPECTIVE.Acta endocrinologica (Bucharest, Romania : 2005)
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ayush GuptaDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Arnab GhoshDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Gagandeep SinghDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Immaculata XessDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, India. immaxess.isham@gmail.com.
All India Institute of Medical Sciences · IN

Funding

NIL NIL
6 · The paper itself

Abstract

purposePublished literature lacks systematic studies on disseminated histoplasmosis in India, and previous reviews on its epidemiology in India were conducted two decades back. Thus, we review the Indian studies published in this century to understand the recent epidemiology of histoplasmosis in India and do a retrospective analysis of all cases diagnosed at our institute.

methodsA literature of review search was done in Pubmed/Medline and Scopus. Studies published during January 2001-December 2015 were considered along with retrospective analysis of cases presented to us. A distinction was made in the clinical presentation of immunocompetent and immunocompromised cases.

resultsNinety-five included studies described 204 cases, and 10 cases from our retrospective analysis were included. The mean age at presentation was 45.1 ± 15.4 years [range 3-83, median 45, interquartile range 37-55], and male-to-female ratio was 6:1. Most cases were reported from northern and northeastern states of India along the rivers Ganges, Yamuna and Brahmaputra and in people associated with agricultural activity. About 33% of cases were immunocompromised, out of which immunosuppression due to HIV was seen in 72% cases. The mean age of presentation was significantly lower in immunocompromised cases (37.9 vs. 49.2 years; p < 0.00001, Mann-Whitney test), and mortality was also higher (10 vs. 27.5%, p = 0.01, Fisher's exact test). Adrenal involvement was in significantly higher proportion of immunocompetent patients compared to immunocompromised population.

conclusionsDisseminated histoplasmosis is being increasingly recognized in India. There is a need to undertake well-designed, analytical studies utilizing appropriate diagnostic modalities to understand the epidemiology of this neglected disease in proper perspective.

Indexed as

AdolescentAdultAgedAged, 80 and overAntifungal AgentsChildChild, PreschoolFarmersFemaleHistoplasmosisHIV InfectionsHumansImmunocompromised HostIndiaMaleMiddle AgedAntifungal AgentsDevelopingEpidemiologyHistoplasmosisReviewSystematic

Identifiers

PMID29080114
OpenAlexW2765410949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.