ArticleLasers in medical science2018
Rapid analysis of pharmaceutical drugs using LIBS coupled with multivariate analysis.
Article in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A high-temperature optical cell for chemical analysis of vapor using combined spectroscopy approaches.RSC advances · 2025Article
- Compositional analysis of copper and iron-based alloys using LIBS coupled with chemometric method.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Evaluation of Na and K in anti-diabetic ayurvedic medicine using LIBS.Lasers in medical science · 2022Article
- Application of Scikit and Keras Libraries for the Classification of Iron Ore Data Acquired by Laser-Induced Breakdown Spectroscopy (LIBS).Sensors (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes drug tablets containing voglibose having dose strengths of 0.2 and 0.3 mg of various brands have been examined, using laser-induced breakdown spectroscopy (LIBS) technique. The statistical methods such as the principal component analysis (PCA) and the partial least square regression analysis (PLSR) have been employed on LIBS spectral data for classifying and developing the calibration models of drug samples. We have developed the ratio-based calibration model applying PLSR in which relative spectral intensity ratios H/C, H/N and O/N are used. Further, the developed model has been employed to predict the relative concentration of element in unknown drug samples. The experiment has been performed in air and argon atmosphere, respectively, and the obtained results have been compared. The present model provides rapid spectroscopic method for drug analysis with high statistical significance for online control and measurement process in a wide variety of pharmaceutical industrial applications.
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Registered trials
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