Evidence map›Paper›PMID 29079990›Full record

Trial reportProbiotics and antimicrobial proteins2019

The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial.

Alireza Farrokhian, Fariba Raygan, Ali Soltani, Maryam Tajabadi-Ebrahimi, Mehran Sharifi Esfahani, Ali Akbar Karami, Zatollah Asemi

RetractedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Probiotics and antimicrobial proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alireza FarrokhianDepartment of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R., Iran.
Fariba RayganDepartment of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R., Iran.
Ali SoltaniResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.
Maryam Tajabadi-EbrahimiScience Department, Science Faculty, Islamic Azad University, Tehran Central Branch, Tehran, Iran.
Mehran Sharifi EsfahaniDepartment of Oncology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Ali Akbar KaramiDepartment of Urology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Zatollah AsemiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran. asemi_r@yahoo.com.
Kashan University of Medical Sciences · IRIslamic Azad University Central Tehran Branch · IRQazvin University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85 years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 10

Indexed as

Carotid Intima-Media ThicknessOxidative StressAgedAged, 80 and overBiomarkersCoronary DiseaseC-Reactive ProteinDiabetes MellitusDietary SupplementsDouble-Blind MethodFemaleHumansMaleMalondialdehydeMiddle AgedOverweightBiomarkersC-Reactive ProteinMalondialdehydeCarotid intima-media thicknessCoronary heart diseaseInflammationOxidative stressSynbiotic supplementationType 2 diabetes mellitus

Identifiers

PMID29079990
OpenAlexW2765729966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.