ArticleInvestigative ophthalmology & visual science2017
Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Quantifying Lateral Pulsation in Retinal Vessels Within the Optic Disc.Translational vision science & technology · 2026Article
- Proteomic clocks combined with deep learning phenotypes track eye aging and diseases.NPJ digital medicine · 2026Article
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Racial Variations in Retinal Oxygen Metabolic Biomarkers in Diabetic Retinopathy: A Pilot Study.Journal of ophthalmology · 2026Article
- Establishment of a RBL-formula to determine the retinal breaks location for scleral buckling surgery.International ophthalmology · 2025Article
- A Method for Peripapillary Retinal Vessel Tortuosity Measurement and Its Clinical Correspondence.Translational vision science & technology · 2025Article
- Multimodal retinal imaging by visible light optical coherence tomography and phosphorescence lifetime ophthalmoscopy in the mouse eye.Neurophotonics · 2025Article
- Retinal Vessel Flicker Light Responsiveness and Its Relation to Analysis Protocols and Static and Metabolic Data in Healthy Subjects.Biomedicines · 2025Article
- Hemoglobin oxygen saturation in myopic eyes: a scanning laser ophthalmoscope study.International journal of ophthalmology · 2025Article
- Retinal Vessel Caliber Measurement Bias in Fundus Images in the Presence of the Central Light Reflex.Translational vision science & technology · 2023Article
- Ophthalmic imaging in diabetic retinopathy: A review.Clinical & experimental ophthalmology · 2022Review
- Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats.Investigative ophthalmology & visual science · 2022Article
- Retinal Oxygen Delivery and Extraction in Ophthalmologically Healthy Subjects With Different Blood Pressure Status.Translational vision science & technology · 2022Article
- Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy.Investigative ophthalmology & visual science · 2021Article
- Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy.Translational vision science & technology · 2021Article
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Article
- Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study.American journal of ophthalmology · 2020Article
- Assessment of retinal vascular oxygenation and morphology at stages of diabetic retinopathy in African Americans.BMC ophthalmology · 2020Article
- Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular Microvasculature: An Optical Coherence Tomography Angiography Study.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Purpose: To test the hypothesis that retinal vascular diameter and hemoglobin oxygen saturation alterations, according to stages of diabetic retinopathy (DR), are discernible with a commercially available scanning laser ophthalmoscope (SLO). Methods: One hundred eighty-one subjects with no diabetes (No DM), diabetes with no DR (No DR), nonproliferative DR (NPDR), or proliferative DR (PDR, all had photocoagulation) underwent imaging with an SLO with dual lasers (532 nm and 633 nm). Customized image analysis software determined the diameters of retinal arteries and veins (DA and DV) and central retinal artery and vein equivalents (CRAE and CRVE). Oxygen saturations of hemoglobin in arteries and veins (SO2A and SO2V) were estimated from optical densities of vessels on images at the two wavelengths. Statistical models were generated by adjusting for effects of sex, race, age, eye, and fundus pigmentation. Results: DA, CRAE, and CRVE were reduced in PDR compared to No DM (P ≤ 0.03). DV and CRVE were similar between No DM and No DR, but they were higher in NPDR than No DR (P ≤ 0.01). Effect of stage of disease on SO2A differed by race, being increased relative to No DM in NPDR and PDR in Hispanic participants only (P ≤ 0.02). Relative to No DM, SO2V was increased in NPDR and PDR (P ≤ 0.05). Conclusions: Alterations in retinal vascular diameters and SO2 by diabetic retinopathy stage can be detected with a widely available SLO, and covariates such as race can influence the results.
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