Evidence map›Paper›PMID 29079833›Full record

ArticleNature communications2017

Real-time observation of polymerase-promoter contact remodeling during transcription initiation.

Cong A Meng, Furqan M Fazal, Steven M Block

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Real-time 3D single molecule tracking.Nature communications · 2020
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cong A MengDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Furqan M FazalDepartment of Applied Physics, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-0758-4582
Steven M BlockDepartment of Applied Physics, Stanford University, Stanford, CA, 94305, USA. sblock@stanford.edu.
Stanford University · US

Funding

Nucleic Acid Enzymes and Nucleic Acids Studied at the Molecular LevelR37GM057035 · NIGMS · STANFORD UNIVERSITY · PI BLOCK, STEVEN M · 2010 to 2019
$5.7M
TRANSCRIPTION STUDIED AT THE MOLECULAR LEVELR01GM057035 · NIGMS · STANFORD UNIVERSITY · PI BLOCK, STEVEN M · 1997 to 2009
$3.3M
NIGMS NIH HHS R01 GM057035NIGMS NIH HHS R37 GM057035
6 · The paper itself

Abstract

Critical contacts made between the RNA polymerase (RNAP) holoenzyme and promoter DNA modulate not only the strength of promoter binding, but also the frequency and timing of promoter escape during transcription. Here, we describe a single-molecule optical-trapping assay to study transcription initiation in real time, and use it to map contacts formed between σ

Indexed as

Promoter Regions, GeneticTranscription Initiation, GeneticDNADNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliHoloenzymesProtein BindingSigma FactorDNADNA, BacterialDNA-Directed RNA PolymerasesHoloenzymesSigma Factor

Identifiers

PMID29079833
PMCPMC5660091
OpenAlexW2766309792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.